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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Plasma neutrophil gelatinase-associated lipocalin as an early biomarker for prediction of acute kidney injury after cardio-pulmonary bypass in pediatric cardiac surgery
Archives of Medical Science, Volume 8, No. 2, Year 2012
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Description
Introduction: Cardiopulmonary bypass (CPB) surgery is considered one of the most frequent surgical procedures in which acute kidney injury (AKI) represents a frequent and serious complication. The aim of the present study was to evaluate the efficiency of neutrophil gelatinase-associated lipocalin (NGAL) as an early AKI biomarker after CPB in pediatric cardiac surgery. Material and methods: The study included forty children aged 2 to 78 months undergoing CPB. They were divided into group I: patients who suffered AKI grades II and III; and group II: patients who did not develop AKI or at risk. Peripheral venous blood was withdrawn pre- and post-operatively for serial measurements of NGAL and creatinine. Statistical analysis was performed using Statistical Package for Social Sciences version 14. Results: Mean plasma NGAL levels showed highly significant elevations in group I patients at 2, 12, and 24 h after surgery (p < 0.0001) compared to group II. Significant correlations were found between NGAL and creatinine at different time intervals. Highly significant correlations (p < 0.0001) were found between plasma NGAL and AKI at 2, 12 and 24 h after surgery. A cut-off level of 100 ng/ml at 2 h, and 125 ng/ml at 12 h post-operatively both recorded the highest accuracy, being 95% accurate, with sensitivity of 100% and 89.5% respectively, and specificity of 90.5% and 100% respectively. Conclusions: This study showed that plasma NGAL could be used as an early biomarker for detection of AKI following CPB. We recommend further studies on a wider scale to validate the current study results. Copyright © 2012 Termedia & Banach.
Authors & Co-Authors
Fadel, Fatina Ibrahim
Egypt, Cairo
Faculty of Medicine
Abdel-Rahman, Azza Mohamed Omar
Egypt, Giza
National Research Centre
Mohamed, Mohamed Farouk
Egypt, Cairo
Faculty of Medicine
Habib, Sonia Adolf
Egypt, Giza
National Research Centre
Farag, Mona H.
Egypt, Giza
National Research Centre
Sleem, Zeinab S.
Egypt, Cairo
Faculty of Medicine
Bazaraa, Hafez Mahmoud
Egypt, Cairo
Faculty of Medicine
Soliman, Mohammed Mosad A.
Egypt, Giza
National Research Centre
Statistics
Citations: 46
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.5114/aoms.2012.28552
ISSN:
17341922
Research Areas
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Violence And Injury
Study Approach
Quantitative