Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Evolving epidemiology of poliovirus serotype 2 following withdrawal of the serotype 2 oral poliovirus vaccine
Science, Volume 368, No. 6489, Year 2020
Notification
URL copied to clipboard!
Description
Although there have been no cases of serotype 2 wild poliovirus for more than 20 years, transmission of serotype 2 vaccine-derived poliovirus (VDPV2) and associated paralytic cases in several continents represent a threat to eradication. The withdrawal of the serotype 2 component of oral poliovirus vaccine (OPV2) was implemented in April 2016 to stop VDPV2 emergence and secure eradication of all serotype 2 poliovirus. Globally, children born after this date have limited immunity to prevent transmission. Using a statistical model, we estimated the emergence date and source of VDPV2s detected between May 2016 and November 2019. Outbreak response campaigns with monovalent OPV2 are the only available method to induce immunity to prevent transmission. Yet our analysis shows that using monovalent OPV2 is generating more paralytic VDPV2 outbreaks with the potential for establishing endemic transmission. A novel OPV2, for which two candidates are currently in clinical trials, is urgently required, together with a contingency strategy if this vaccine does not materialize or perform as anticipated. Copyright © 2020 The Authors,
Authors & Co-Authors
Macklin, G. R.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Switzerland, Geneva
Organisation Mondiale de la Santé
O’Reilly, Kathleen M.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Grassly, Nicholas C.
United Kingdom, London
Imperial College London
Edmunds, William John
United Kingdom, London
London School of Hygiene & Tropical Medicine
MacH, Ondrej
Switzerland, Geneva
Organisation Mondiale de la Santé
Voorman, Arend
Unknown Affiliation
Vertefeuille, John F.
United States, Atlanta
Centers for Disease Control and Prevention
Abdelwahab, Jalaa A.
United States, New York
Unicef
Gumede, Nicksy
Congo, Brazzaville
World Health Organization Regional Office for Africa Congo
Goel, Ajay Kumar
Switzerland, Geneva
Organisation Mondiale de la Santé
Sosler, Stephen M.
Switzerland, Geneva
Global Alliance for Vaccines and Immunization Gavi
Bandyopadhyay, Ananda S.
Unknown Affiliation
Pallansch, Mark A.
United States, Atlanta
Centers for Disease Control and Prevention
Nandy, Robin K.
United States, New York
Unicef
Mkanda, Pascal
Congo, Brazzaville
World Health Organization Regional Office for Africa Congo
Diop, Ousmane Madiagne
Switzerland, Geneva
Organisation Mondiale de la Santé
Sutter, Roland Walter
Switzerland, Geneva
Organisation Mondiale de la Santé
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 75
Authors: 17
Affiliations: 7
Identifiers
Doi:
10.1126/science.aba1238
ISSN:
00368075
Research Areas
Health System And Policy
Maternal And Child Health