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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Development and validation of a liquid chromatography method with electrospray ionization tandem mass spectrometry for the determination of brotizolam residues in beef and commercial whole milk
Biomedical Chromatography, Volume 25, No. 9, Year 2011
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Description
In this work, a liquid chromatography-tandem mass spectrometric detection technique was developed and validated for the determination of brotizolam residues in beef muscle and commercial whole milk. This procedure involves the extraction of the analyte from the samples via liquid-solid extraction, and caffeine was used as an internal standard. The analyte was successfully separated on an XTerra-C18 column, with a mobile phase composed of 0.01% formic acid in acetonitrile and 1mm ammonium formate-0.01% formic acid in water. The one-step extraction method evidenced good selectivity, precision (RSD = 9.87-26.47%), and the recovery of the extractable analyte was 92.61-115.98% in the matrices. The limits of quantification ranged between 0.4 and 0.5μg/kg. The developed method is simple since it requires no additional cleanup procedures. © 2011 John Wiley & Sons, Ltd.
Authors & Co-Authors
Cho, Hee-jung
South Korea, Seoul
Konkuk University
Jo, Kyul
South Korea, Seoul
Konkuk University
Yi, Hee
South Korea, Seoul
Konkuk University
Cho, Soo Min
South Korea, Seoul
Konkuk University
Abd El-Aty, A. M.
Egypt, Giza
Faculty of Veterinary Medicine
Kim, Min Kyung
South Korea, Seoul
Chung-ang University
Han, Sang Beom
South Korea, Seoul
Chung-ang University
Oh, Jae Ho
South Korea, Seoul
National Institute of Food and Drug Safety Evaluation
Kwon, Chan-hyeok
South Korea, Seoul
National Institute of Food and Drug Safety Evaluation
Shim, Jae-Han
South Korea, Gwangju
Chonnam National University
Shin, Ho-chul
South Korea, Seoul
Konkuk University
Statistics
Citations: 11
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1002/bmc.1579
ISSN:
02693879
e-ISSN:
10990801
Research Areas
Environmental