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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Analysis of genetic linkage of HIV from couples enrolled in the HIV prevention trials network 052 trial
Journal of Infectious Diseases, Volume 204, No. 12, Year 2011
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Description
Background. The HIV Prevention Trials Network (HPTN) 052 trial demonstrated that early initiation of antiretroviral therapy (ART) reduces human immunodeficiency virus (HIV) transmission from HIV-infected adults (index participants) to their HIV-uninfected sexual partners. We analyzed HIV from 38 index-partner pairs and 80 unrelated index participants (controls) to assess the linkage of seroconversion events. Methods. Linkage was assessed using phylogenetic analysis of HIV pol sequences and Bayesian analysis of genetic distances between pol sequences from index-partner pairs and controls. Selected samples were also analyzed using next-generation sequencing (env region). Results. In 29 of the 38 (76.3%) cases analyzed, the index was the likely source of the partner's HIV infection (linked). In 7 cases (18.4%), the partner was most likely infected from a source other than the index participant (unlinked). In 2 cases (5.3%), linkage status could not be definitively established. Conclusions. Nearly one-fifth of the seroconversion events in HPTN 052 were unlinked. The association of early ART and reduced HIV transmission was stronger when the analysis included only linked events. This underscores the importance of assessing the genetic linkage of HIV seroconversion events in HIV prevention studies involving serodiscordant couples. © 2011 The Author.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3209811/bin/supp_204_12_1918__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3209811/bin/supp_jir651_Supplemental_File_1.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3209811/bin/supp_jir651_Supplemental_File_2.doc
Authors & Co-Authors
Eshleman, Susan H.
United States, Baltimore
Johns Hopkins University
Hudelson, Sarah E.
United States, Baltimore
Johns Hopkins University
Redd, Andrew D.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Wang, Lei
United States, Seattle
Fred Hutchinson Cancer Research Center
Debes, Rachel
United States, Seattle
University of Washington
Chen, Yingqing
United States, Seattle
Fred Hutchinson Cancer Research Center
Martens, Craig A.
United States, Hamilton
Niaid Rocky Mountain Laboratories
Ricklefs, Stacy M.
United States, Hamilton
Niaid Rocky Mountain Laboratories
Selig, Ethan J.
United States, Hamilton
Niaid Rocky Mountain Laboratories
Porcella, Stephen F.
United States, Hamilton
Niaid Rocky Mountain Laboratories
Munshaw, Supriya
United States, Baltimore
Johns Hopkins School of Medicine
Ray, Stuart C.
United States, Baltimore
Johns Hopkins School of Medicine
Piwowar-Manning, Estelle M.
United States, Baltimore
Johns Hopkins University
McCauley, Marybeth B.
United States, Durham
Fhi 360
Hosseinipour, Mina C.
Malawi, Lilongwe
Kamuzu Central Hospital
Kumwenda, Johnstone J.
Malawi, Zomba
University of Malawi
Hakim, James Gita
Zimbabwe, Harare
University of Zimbabwe
Chariyalertsak, Suwat
Thailand, Chaing Mai
Chiang Mai University
De Bruyn, Guy
South Africa, Johannesburg
University of the Witwatersrand
Grinsztejn, Beatriz Gilda Jegerhorn
Brazil, Rio de Janeiro
Instituto Nacional de Infectologia Evandro Chagas Ini
Kumarasamy, Nagalingeswaran
India, Chennai
Vhs Medical Centre India
Makhema, Joseph M.
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Mayer, Kenneth H.
United States, Boston
Fenway Community Health Center
Pilotto, José Henrique S.
Brazil, Rio de Janeiro
Hospital Geral de Rio de Janeiro
Santos, Breno Riegel
Brazil, Tubarao
Hospital Nossa Senhora da Conceicao
Quinn, Thomas Charles
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Baltimore
Johns Hopkins School of Medicine
Cohen, Myron S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Hughes, James P.
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Statistics
Citations: 116
Authors: 28
Affiliations: 19
Identifiers
Doi:
10.1093/infdis/jir651
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases
Sexual And Reproductive Health