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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Durable SARS-CoV-2 B cell immunity after mild or severe disease
Journal of Clinical Investigation, Volume 131, No. 7, Article e145516, Year 2021
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Description
Multiple studies have shown loss of severe acute respiratory syndrome coronavirus 2-specific (SARS-CoV-2-specific) antibodies over time after infection, raising concern that humoral immunity against the virus is not durable. If immunity wanes quickly, millions of people may be at risk for reinfection after recovery from coronavirus disease 2019 (COVID-19). However, memory B cells (MBCs) could provide durable humoral immunity even if serum neutralizing antibody titers decline. We performed multidimensional flow cytometric analysis of S protein receptor binding domain-specific (S-RBD-specific) MBCs in cohorts of ambulatory patients with COVID-19 with mild disease (n = 7), and hospitalized patients with moderate to severe disease (n = 7), at a median of 54 days (range, 39-104 days) after symptom onset. We detected S-RBD-specific class-switched MBCs in 13 of 14 participants, failing only in the individual with the lowest plasma levels of anti-S-RBD IgG and neutralizing antibodies. Resting MBCs (rMBCs) made up the largest proportion of S-RBD-specific MBCs in both cohorts. FCRL5, a marker of functional memory on rMBCs, was more dramatically upregulated on S-RBD-specific rMBCs after mild infection than after severe infection. These data indicate that most SARS-CoV-2-infected individuals develop S-RBD-specific, class-switched rMBCs that resemble germinal center-derived B cells induced by effective vaccination against other pathogens, providing evidence for durable B cell-mediated immunity against SARS-CoV-2 after mild or severe disease. Copyright: © 2021, American Society for Clinical Investigation.
Authors & Co-Authors
Blair, Paul W.
United States, Baltimore
Johns Hopkins University
Dhakal, Santosh
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Antar, Annukka A.R.
United States, Baltimore
Johns Hopkins University
Ray, Stuart C.
United States, Baltimore
Johns Hopkins University
Betenbaugh, Michael James
United States, Baltimore
Johns Hopkins University
Pekosz, Andrew S.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Klein, Sabra L.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Manabe, Yukari C.
United States, Baltimore
Johns Hopkins University
Cox, Andrea L.
United States, Baltimore
Johns Hopkins University
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Bailey, Justin R.
United States, Baltimore
Johns Hopkins University
Statistics
Citations: 59
Authors: 10
Affiliations: 2
Identifiers
Doi:
10.1172/JCI145516
ISSN:
00219738
Research Areas
Covid
Study Design
Cohort Study