Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The role of age and exposure to Plasmodium falciparum in the rate of acquisition of naturally acquired immunity: A randomized controlled trial
PLoS ONE, Volume 7, No. 3, Article e32362, Year 2012
Notification
URL copied to clipboard!
Description
Background: The rate of acquisition of naturally acquired immunity (NAI) against malaria predominantly depends on transmission intensity and age, although disentangling the effects of these is difficult. We used chemoprophylaxis to selectively control exposure to P. falciparum during different periods in infancy and explore the effect of age in the build-up of NAI, measured as risk of clinical malaria. Methods and Findings: A three-arm double-blind randomized placebo-controlled trial was conducted in 349 infants born to Mozambican HIV-negative women. The late exposure group (LEG) received monthly Sulfadoxine-Pyrimethamine (SP) plus Artesunate (AS) from 2.5-4.5 months of age and monthly placebo from 5.5-9.5 months; the early exposure group (EEG) received placebo from 2.5-4.5 months and SP+AS from 5.5-9.5 months; and the control group (CG) received placebo from 2.5-9.5 months. Active and passive case detection (PCD) were conducted from birth to 10.5 and 24 months respectively. The primary endpoint was time to first or only episode of malaria in the second year detected by PCD. The incidence of malaria during the second year was of 0.50, 0.51 and 0.35 episodes/PYAR in the LEG, EEG and CG respectively (p = 0.379 for the adjusted comparison of the 3 groups). The hazard ratio of the adjusted comparison between the LEG and the CG was 1.38 (0.83-2.28, p = 0.642) and that between the EEG and the CG was 1.35 (0.81-2.24, p = 0.743). Conclusions: After considerably interfering with exposure during the first year of life, there was a trend towards a higher risk of malaria in the second year in children who had received chemoprophylaxis, but there was no significant rebound. No evidence was found that the age of first exposure to malaria affects the rate of acquisition of NAI. Thus, the timing of administration of antimalarial interventions like malaria vaccines during infancy does not appear to be a critical determinant. © 2012 Guinovart et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3296698/bin/pone.0032362.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3296698/bin/pone.0032362.s002.pdf
Authors & Co-Authors
Guinovart, Caterina
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Dobaño, Carlota
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Bassat, Quique
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Nhabomba, Augusto J.
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Quintò, Llorenç L.
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Manaca, Maria Nélia
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Aguilar, Ruth
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Rodríguez, Mauricio H. Humberto
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Barbosa, Arnoldo
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Aponte, John Jairo
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Mayor, A. G.
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Renom, Montse
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Moraleda, Cinta
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Roberts, David J.
United Kingdom, Oxford
John Radcliffe Hospital
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Schwarzer, Evelin
Italy, Turin
Università Degli Studi Di Torino, Scuola Di Medicina
Le Souf, Peter N.
Australia, Perth
The University of Western Australia
Schofield, Louis
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Chitnis, Chetan E.
Italy, Trieste
International Centre for Genetic Engineering and Biotechnology
Doolan, Denise L.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Alonso, Pedro Luís
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Statistics
Citations: 32
Authors: 20
Affiliations: 10
Identifiers
Doi:
10.1371/journal.pone.0032362
e-ISSN:
19326203
Research Areas
Disability
Environmental
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Cohort Study
Study Approach
Quantitative
Participants Gender
Female