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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts
mBio, Volume 2, No. 1, Article e00342-10, Year 2011
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Description
Cryptococcus gattii recently emerged as the causative agent of cryptococcosis in healthy individuals in western North America, despite previous characterization of the fungus as a pathogen in tropical or subtropical regions. As a foundation to study the genetics of virulence in this pathogen, we sequenced the genomes of a strain (WM276) representing the predominant global molecular type (VGI) and a clinical strain (R265) of the major genotype (VGIIa) causing disease in North America. We compared these C. gattii genomes with each other and with the genomes of representative strains of the two varieties of Cryptococcus neoformans that generally cause disease in immunocompromised people. Our comparisons included chromosome alignments, analysis of gene content and gene family evolution, and comparative genome hybridization (CGH). These studies revealed that the genomes of the two representative C. gattii strains (genotypes VGI and VGIIa) are colinear for the majority of chromosomes, with some minor rearrangements. However, multiortholog phylogenetic analysis and an evaluation of gene/sequence conservation support the existence of speciation within the C. gattii complex. More extensive chromosome rearrangements were observed upon comparison of the C. gattii and the C. neoformans genomes. Finally, CGH revealed considerable variation in clinical and environmental isolates as well as changes in chromosome copy numbers in C. gattii isolates displaying fluconazole heteroresistance. © 2011 D'Souza et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3037005/bin/mBio00342-10-s1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3037005/bin/mBio00342-10-s2.rtf
https://efashare.b-cdn.net/share/pmc/articles/PMC3037005/bin/mBio00342-10-s3.rtf
https://efashare.b-cdn.net/share/pmc/articles/PMC3037005/bin/mBio00342-10-st01.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3037005/bin/mBio00342-10-st02.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3037005/bin/mBio00342-10-st03.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3037005/bin/mBio00342-10-sd1.xlsx
Authors & Co-Authors
Kronstad, James W.
Canada, Vancouver
The University of British Columbia
Warren, René L.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Yuen, Macaire Man Saint
Canada, Vancouver
The University of British Columbia
Jung, Wonhee
South Korea, Seoul
Chung-ang University
Kidd, Sarah E.
Canada, Vancouver
The University of British Columbia
Australia, Sydney
The University of Sydney
Lee, Nelson L.S.
Canada, Vancouver
The University of British Columbia
Shah, Sohrab P.
Canada, Vancouver
The University of British Columbia
Gnerre, Sante
United States, Cambridge
Massachusetts Institute of Technology
Griggs, Allison D.
United States, Cambridge
Massachusetts Institute of Technology
Zeng, Qiandong
United States, Cambridge
Massachusetts Institute of Technology
Li, Wenjun
United States, Durham
Duke University Medical Center
Stajich, Jason E.
United States, Riverside
University of California, Riverside
Fraser, James A.
Australia, Brisbane
The University of Queensland
Meyer, Wieland
Australia, Sydney
The University of Sydney
Carter, Dee A.
Australia, Sydney
The University of Sydney
Schein, Jacqueline E.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Kwon-Chung, Kyung Joo
United States, Bethesda
National Institutes of Health Nih
Varma, Ashok
United States, Bethesda
National Institutes of Health Nih
Brunham, Robert C.
Canada, Vancouver
Bc Centre for Disease Control
Ouellette, Bf Francis
Canada, Vancouver
The University of British Columbia
Canada, Toronto
Ontario Institute for Cancer Research
Marra, Marco A.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Jones, Steven J.M.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Birren, Bruce W.
United States, Cambridge
Massachusetts Institute of Technology
Galagan, James E.
United States, Cambridge
Massachusetts Institute of Technology
Statistics
Citations: 191
Authors: 24
Affiliations: 12
Identifiers
Doi:
10.1128/mBio.00342-10
ISSN:
21507511
Research Areas
Genetics And Genomics