Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The arabidopsis wall associated kinase-like 10 gene encodes a functional guanylyl cyclase and is co-expressed with pathogen defense related genes
PLoS ONE, Volume 5, No. 1, Article e8904, Year 2010
Notification
URL copied to clipboard!
Description
Background: Second messengers have a key role in linking environmental stimuli to physiological responses. One such messenger, guanosine 3′,5′-cyclic monophosphate (cGMP), has long been known to be an essential signaling molecule in many different physiological processes in higher plants, including biotic stress responses. To date, however, the guanylyl cyclase (GC) enzymes that catalyze the formation of cGMP from GTP have largely remained elusive in higher plants. Principal Findings: We have identified an Arabidopsis receptor type wall associated kinase-like molecule (AtWAKL10) as a candidate GC and provide experimental evidence to show that the intracellular domain of AtWAKL10431-700 can generate cGMP in vitro. Further, we also demonstrate that the molecule has kinase activity indicating that AtWAKL10 is a twin-domain catalytic protein. A co-expression and stimulus-specific expression analysis revealed that AtWAKL10 is consistently coexpressed with well characterized pathogen defense related genes and along with these genes is induced early and sharply in response to a range of pathogens and their elicitors. Conclusions: We demonstrate that AtWAKL10 is a twin-domain, kinase-GC signaling molecule that may function in biotic stress responses that are critically dependent on the second messenger cGMP. © 2010 Meier et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2811198/bin/pone.0008904.s001.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC2811198/bin/pone.0008904.s002.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2811198/bin/pone.0008904.s003.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2811198/bin/pone.0008904.s004.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2811198/bin/pone.0008904.s005.doc
Authors & Co-Authors
Meier, Stuart K.
Saudi Arabia, Thuwal
King Abdullah University of Science and Technology
Ruzvidzo, Oziniel
South Africa, Bellville
University of the Western Cape
Morse, Monique V.
South Africa, Bellville
University of the Western Cape
Donaldson, Lara
South Africa, Bellville
University of the Western Cape
Kwezi, Lusisizwe
South Africa, Bellville
University of the Western Cape
Gehring, Chris A.
Saudi Arabia, Thuwal
King Abdullah University of Science and Technology
South Africa, Bellville
University of the Western Cape
Statistics
Citations: 139
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1371/journal.pone.0008904
e-ISSN:
19326203
Research Areas
Genetics And Genomics