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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Validation of candidate smear microscopy quality indicators, extracted from tuberculosis laboratory registers
International Journal of Tuberculosis and Lung Disease, Volume 11, No. 3, Year 2007
Notification
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Description
SETTING: Kinshasa Province, Democratic Republic of Congo. OBJECTIVE: To identify and validate register-based indicators of acid-fast bacilli (AFB) microscopy quality. DESIGN: Selection of laboratories based on reliability and variation in routine smear rechecking results. Calculation of relative sensitivity (RS) compared to recheckers and its correlation coefficient (R) with candidate indicators based on a fully probabilistic analysis incorporating vague prior information using WinBUGS. RESULTS: The proportion of positive follow-up smears correlated well (median R 0.81, 95% credibility interval [CI] 0.58-0.93), and the proportion of first smear-positive cases fairly (median R 0.70, 95% CI 0.38-0.89) with RS. The proportions of both positive suspect and low positive case smears showed poor correlations (median R 0.27 and -0.22, respectively, with ranges including zero). CONCLUSIONS: The proportion of positives in follow-up smears is the most promising indicator of AFB smear sensitivity, while the proportion of positive suspects may be more indicative of accessibility and suspect selection. Both can be obtained from simple reports, and should be used for internal and external monitoring and as guidance for supervision. As proportion of low positive suspect smears and consistency within case series are more difficult to interpret, they should be used only on-site by laboratory professionals. All indicators require more research to define their optimal range in various settings. © 2007 The Union.
Authors & Co-Authors
van Deun, Armand
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
France, Paris
International Union Against Tuberculosis and Lung Disease
Zwahlen, Marcel
Switzerland, Bern
University of Bern
Bola, V.
Chad
Programme National de Lutte Contre la Tuberculose
Lebeke, Rossin
Chad
Programme National de Lutte Contre la Tuberculose
Bahati, Etienne R.
Chad
Programme National de Lutte Contre la Tuberculose
Lubamba, P.
Unknown Affiliation
Rieder, Hans L.
France, Paris
International Union Against Tuberculosis and Lung Disease
Statistics
Citations: 7
Authors: 7
Affiliations: 4
Identifiers
ISSN:
10273719
Study Design
Cohort Study
Study Locations
Congo