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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Moxifloxacin population pharmacokinetics in patients with pulmonary tuberculosis and the effect of intermittent high-dose rifapentine
Antimicrobial Agents and Chemotherapy, Volume 56, No. 8, Year 2012
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Description
We described the population pharmacokinetics of moxifloxacin and the effect of high-dose intermittent rifapentine in patients with pulmonary tuberculosis who were randomized to a continuation-phase regimen of 400 mg moxifloxacin and 900 mg rifapentine twice weekly or 400 mg moxifloxacin and 1,200 mg rifapentine once weekly. A two-compartment model with transit absorption best described moxifloxacin pharmacokinetics. Although rifapentine increased the clearance of moxifloxacin by 8% during antituberculosis treatment compared to that after treatment completion without rifapentine, it did not result in a clinically significant change in moxifloxacin exposure. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Zvada, Simbarashe Peter
South Africa, Cape Town
University of Cape Town
Denti, Paolo
South Africa, Cape Town
University of Cape Town
Geldenhuys, Hennie D.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Meredith, Sandra A.
South Africa, Cape Town
University of Cape Town
van As, Danelle
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hatherill, Mark
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hanekom, Willem Albert
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Wiesner, L. D.
South Africa, Cape Town
University of Cape Town
Simonsson, Ulrika S.H.
Sweden, Uppsala
Uppsala Universitet
Jindani, Amina
United Kingdom, London
St George’s, University of London
Harrison, Thomas Stephen
United Kingdom, London
St George’s, University of London
McIlleron, Helen Margaret
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 33
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1128/AAC.00404-12
ISSN:
00664804
e-ISSN:
10986596
Study Design
Cross Sectional Study