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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Vaginal lavage with chlorhexidine during labour to reduce mother-to-child HIV transmission: Clinical trial in Mombasa, Kenya
AIDS, Volume 15, No. 3, Year 2001
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Description
Objectives: To evaluate the effect of vaginal lavage with diluted chlorhexidine on mother-to child transmission of HIV (MTCT) in a breastfeeding population. Methods: This prospective clinical trial was conducted in a governmental hospital in Mombasa, Kenya. On alternating weeks, women were allocated to non-intervention or to intervention consisting of vaginal lavage with 120 ml 0.2% chlorhexidine, later increased to 0.4%, repeated every 3 h from admission to delivery. Infants were tested for HIV by DNA polymerase chain reaction within 48 h and at 6 and 14 weeks of life. Results: Enrolment and follow-up data were available for 297 and 309 HIV-positive women, respectively, in the non-lavage and the lavage groups. There was no evidence of a difference in intrapartum MTCT (17.2 versus 15.9%, OR 0.9, 95% Cl 0.6-1.4) between the groups. Lavage solely before rupture of the membranes tended towards lower MTCT with chlorhexidine 0.2% (OR 0.6, 95% Cl 0.3-1.1), and even more with chlorhexidine 0.4% (OR 0.1, 95% Cl 0.0-0.9). Conclusion: The need remains for interventions reducing MTCT without HIV testing, often unavailable in countries with a high prevalence of HIV. Vaginal lavage with diluted chlorhexidine during delivery did not show a global effect on MTCT in our study. However, the data suggest that lavage before the membranes are ruptured might be associated with a reduction of MTCT, especially with higher concentrations of chlorhexidine. © 2001 Lippincott Williams & Wilkins.
Authors & Co-Authors
Gaillard, Philippe
Belgium, Ghent
Universiteit Gent
Mwanyumba, Fabian
Kenya, Mombasa
Coast Provincial General Hospital, Kenya
Verhofstede, Chris
Belgium, Ghent
Universiteit Gent
Claeys, Patricia
Belgium, Ghent
Universiteit Gent
Chohan, Vrasha
Kenya, Mombasa
Coast Provincial General Hospital, Kenya
Goetghebeur, Els J.T.
Belgium, Ghent
Universiteit Gent
Mandaliya, Kishor N.
Kenya, Mombasa
Coast Provincial General Hospital, Kenya
Ndinya-Achola, Jeckoniah O.
Kenya, Nairobi
University of Nairobi
Temmerman, Marleen I.L.
Belgium, Ghent
Universiteit Gent
Statistics
Citations: 85
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1097/00002030-200102160-00012
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Locations
Kenya
Participants Gender
Female