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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Distinguishing the cyanobacterial neurotoxin β-N-methylamino-l-alanine (BMAA) from other diamino acids
Toxicon, Volume 57, No. 5, Year 2011
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Description
β-N-methylamino-L-alanine (BMAA) is produced by diverse taxa of cyanobacteria, and has been detected by many investigators who have searched for it in cyanobacterial blooms, cultures and collections. Although BMAA is distinguishable from proteinogenic amino acids and its isomer 2,4-DAB using standard chromatographic and mass spectroscopy techniques routinely used for the analysis of amino acids, we studied whether BMAA could be reliably distinguished from other diamino acids, particularly 2,6-diaminopimelic acid which has been isolated from the cell walls of many bacterial species. We used HPLC-FD, UHPLC-UV, UHPLC-MS, and triple quadrupole tandem mass spectrometry (UHPLC-MS/MS) to differentiate BMAA from the diamino acids 2,6-diaminopimelic acid, N-2(amino)ethylglycine, lysine, ornithine, 2,4-diaminosuccinic acid, homocystine, cystine, tryptophan, as well as other amino acids including asparagine, glutamine, and methionine methylsulfonium. © 2011 Elsevier Ltd.
Authors & Co-Authors
Banack, Sandra Anne
United States, Jackson
Institute for Ethnomedicine
Metcalf, James S.
United States, Jackson
Institute for Ethnomedicine
United States, University
University of Mississippi School of Pharmacy
Spacil, Zdenek
United States, Seattle
University of Washington
Downing, Timothy Grant
South Africa, Gqeberha
Nelson Mandela University
Downing, Simoné
South Africa, Gqeberha
Nelson Mandela University
Long, A.
United States, Jackson
Institute for Ethnomedicine
Nunn, Peter B.
United Kingdom, Portsmouth
University of Portsmouth
Cox, Paul Alan
United States, Jackson
Institute for Ethnomedicine
Statistics
Citations: 63
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1016/j.toxicon.2011.02.005
ISSN:
00410101