Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
New insights into the evolution of Wolbachia infections in filarial nematodes inferred from a large range of screened species
PLoS ONE, Volume 6, No. 6, Article e20843, Year 2011
Notification
URL copied to clipboard!
Description
Background: Wolbachia are intriguing symbiotic endobacteria with a peculiar host range that includes arthropods and a single nematode family, the Onchocercidae encompassing agents of filariases. This raises the question of the origin of infection in filariae. Wolbachia infect the female germline and the hypodermis. Some evidences lead to the theory that Wolbachia act as mutualist and coevolved with filariae from one infection event: their removal sterilizes female filariae; all the specimens of a positive species are infected; Wolbachia are vertically inherited; a few species lost the symbiont. However, most data on Wolbachia and filaria relationships derive from studies on few species of Onchocercinae and Dirofilariinae, from mammals. Methodology/Principal Findings: We investigated the Wolbachia distribution testing 35 filarial species, including 28 species and 7 genera and/or subgenera newly screened, using PCR, immunohistochemical staining, whole mount fluorescent analysis, and cocladogenesis analysis. (i) Among the newly screened Onchocercinae from mammals eight species harbour Wolbachia but for some of them, bacteria are absent in the hypodermis, or in variable density. (ii) Wolbachia are not detected in the pathological model Monanema martini and in 8, upon 9, species of Cercopithifilaria. (iii) Supergroup F Wolbachia is identified in two newly screened Mansonella species and in Cercopithifilaria japonica. (iv) Type F Wolbachia infect the intestinal cells and somatic female genital tract. (v) Among Oswaldofilariinae, Waltonellinae and Splendidofilariinae, from saurian, anuran and bird respectively, Wolbachia are not detected. Conclusions/Significance: The absence of Wolbachia in 63% of onchocercids, notably in the ancestral Oswaldofilariinae estimated 140 mya old, the diverse tissues or specimens distribution, and a recent lateral transfer in supergroup F Wolbachia, modify the current view on the role and evolution of the endosymbiont and their hosts. Further genomic analyses on some of the newly sampled species are welcomed to decipher the open questions. © 2011 Ferri et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3120775/bin/pone.0020843.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3120775/bin/pone.0020843.s002.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3120775/bin/pone.0020843.s003.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3120775/bin/pone.0020843.s004.doc
Authors & Co-Authors
Ferri, Emanuele
Italy, Milan
Università Degli Studi Di Milano-bicocca
Bain, Odile
France, Paris
Museum National D'histoire Naturelle
Barbuto, M.
Italy, Milan
Università Degli Studi Di Milano-bicocca
Martin, Coralie
France, Paris
Museum National D'histoire Naturelle
Lo, Nathan
Australia, Sydney
The University of Sydney
Uni, Shigehiko
Japan, Osaka
Osaka Metropolitan University Graduate School of Medicine
Landmann, Frédéric
United States, Santa Cruz
University of California, Santa Cruz
Baccei, Sara G.
Italy, Milan
Università Degli Studi Di Milano-bicocca
Guerrero, Ricardo
Venezuela, Caracas
Universidad Central de Venezuela
de Souza Lima, Sueli
Brazil, Juiz de Fora
Universidade Federal de Juiz de Fora
Bandi, C.
Italy, Milan
Università Degli Studi Di Milano
Wanji, Samuel
Cameroon
Research Foundation in Tropical Diseases and Environment
Diagne, Moustapha C.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Casiraghi, Maurizio
Italy, Milan
Università Degli Studi Di Milano-bicocca
Statistics
Citations: 162
Authors: 14
Affiliations: 10
Identifiers
Doi:
10.1371/journal.pone.0020843
e-ISSN:
19326203
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Participants Gender
Female