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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans
PLoS Pathogens, Volume 3, No. 2, Year 2007
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Description
The fungal pathogens Aspergillus fumigatus and Candida albicans are major health threats for immune-compromised patients. Normally, macrophages and neutrophil granulocytes phagocytose inhaled Aspergillus conidia in the two-dimensional (2-D) environment of the alveolar lumen or Candida growing in tissue microabscesses, which are composed of a three-dimensional (3-D) extracellular matrix. However, neither the cellular dynamics, the per-cell efficiency, the outcome of this interaction, nor the environmental impact on this process are known. Live imaging shows that the interaction of phagocytes with Aspergillus or Candida in 2-D liquid cultures or 3-D collagen environments is a dynamic process that includes phagocytosis, dragging, or the mere touching of fungal elements. Neutrophils and alveolar macrophages efficiently phagocytosed or dragged Aspergillus conidia in 2-D, while in 3-D their function was severely impaired. The reverse was found for phagocytosis of Candida. The phagocytosis rate was very low in 2-D, while in 3-D most neutrophils internalized multiple yeasts. In competitive assays, neutrophils primarily incorporated Aspergillus conidia in 2-D and Candida yeasts in 3-D despite frequent touching of the other pathogen. Thus, phagocytes show activity best in the environment where a pathogen is naturally encountered. This could explain why "delocalized" Aspergillus infections such as hematogeneous spread are almost uncontrollable diseases, even in immunocompetent individuals. © 2007 Behnsen et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC1790725/bin/ppat.0030013.sv001.avi
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Authors & Co-Authors
Behnsen, Judith
Germany, Jena
Leibniz-institut Für Naturstoff-forschung Und Infektionsbiologie E. V. – Hans-knöll-institut
Narang, Priyanka
Germany, Braunschweig
Helmholtz Centre for Infection Research Hzi
Hasenberg, Mike
Germany, Braunschweig
Helmholtz Centre for Infection Research Hzi
Gunzer, Frank
Egypt, New Cairo
German University in Cairo
Bilitewski, Ursula
Germany, Braunschweig
Helmholtz Centre for Infection Research Hzi
Klippel, Nina
Germany, Braunschweig
Helmholtz Centre for Infection Research Hzi
Rohde, Manfred
Germany, Braunschweig
Helmholtz Centre for Infection Research Hzi
Brock, Matthias
Germany, Jena
Leibniz-institut Für Naturstoff-forschung Und Infektionsbiologie E. V. – Hans-knöll-institut
Brakhage, Axel A.
Germany, Jena
Leibniz-institut Für Naturstoff-forschung Und Infektionsbiologie E. V. – Hans-knöll-institut
Gunzer, Matthias
Germany, Braunschweig
Helmholtz Centre for Infection Research Hzi
Statistics
Citations: 107
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1371/journal.ppat.0030013
ISSN:
15537366
e-ISSN:
15537374