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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Diversity of V3 Region Sequences of Human Immunodeficiency Viruses Type 1 from the Central African Republic
AIDS Research and Human Retroviruses, Volume 9, No. 10, Year 1993
Notification
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Description
Nucleotide sequences of the central portion of gp120, including the third hypervariable (V3) loop, were obtained from lymphocytes cocultivated with SupT1 cells from 29 AIDS patients in Bangui, Central African Republic. These sequences displayed significantly greater diversity (average distance, 23%) than has been previously observed in isolates from comparably restricted geographical areas. Isolates belonging to four major subtypes of HIV-1 were found; the only subtype not represented was the North American/European subtype B. Unlike the situation in Zaire and Uganda, where subtypes A and D account equally for virtually all isolates of HIV-1, the predominant subtypes in the Central African Republic, accounting for two-thirds of the isolates, were subtypes A (10 isolates) and E (9 isolates). Subtype E represents a group of variants that have previously been found only in Thailand. Only one isolate belonging to subtype D was found. Also recovered were two isolates of subtype C, a subtype associated with southern African and Indian isolates but not previously detected in central Africa. These isolates, although clearly clustering with subtype C, formed a distinct subset, differing from one another by 8.8% and from the Indian and South African subtype C isolates by an average of 22.5%. High interpatient, intrasubtype variation was also seen among the CAR subtype A (average pairwise difference, 19.3%) and subtype E (10.9%) isolates. The diversity of V3 sequences in this set has implications for immunization protocols that rely on the recognition of V3. This study underscores the necessity of basing intervention strategies on knowledge of the particular sequences present in the target population or geographical area. © 1993, Mary Ann Liebert, Inc. All rights reserved.
Authors & Co-Authors
Murphy, Ellen
United States, Newark
Public Health Research Institute
Korber, Bette T.
United States, Los Alamos
Los Alamos National Laboratory
United States, Santa fe
Santa fe Institute
Georges-Courbot, Marie Claude
Central African Republic, Bangui
Institut Pasteur de Bangui
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
You, Bruno
Central African Republic, Bangui
Institut Pasteur de Bangui
Pinter, Abraham
United States, Newark
Public Health Research Institute
Cook, Debra
United States, Newark
Public Health Research Institute
Kiény, Marie Paule
France, Strasbourg
Transgene sa
Georges, Alain Jean
Central African Republic, Bangui
Institut Pasteur de Bangui
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Mathiot, Christian C.
Central African Republic, Bangui
Institut Pasteur de Bangui
Barré-Sinoussi, Françoise C.
France, Paris
Institut Pasteur, Paris
Girard, Marc P.
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 139
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1089/aid.1993.9.997
ISSN:
08892229
e-ISSN:
19318405
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Cross Sectional Study
Study Locations
Central African Republic
Uganda