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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Serotype specificity of antibodies against foot-and-mouth disease virus in cattle in selected districts in Uganda
Transboundary and Emerging Diseases, Volume 57, No. 5, Year 2010
Notification
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Description
Uganda had an unusually large number of foot-and-mouth disease (FMD) outbreaks in 2006, and all clinical reports were in cattle. A serological investigation was carried out to confirm circulating antibodies against foot-and-mouth disease virus (FMDV) by ELISA for antibodies against non-structural proteins and structural proteins. Three hundred and forty-nine cattle sera were collected-from seven districts in Uganda, and 65% of these were found positive for antibodies against the non-structural proteins of FMDV. A subset of these samples were analysed for serotype specificity of the identified antibodies. High prevalences of antibodies against non-structural proteins and structural proteins of FMDV serotype O were demonstrated in herds with typical visible clinical signs of FMD, while prevalences were low in herds without clinical signs of FMD. Antibody titres were higher against serotype O than against serotypes SAT 1, SAT 2 and SAT 3 in the sera investigated for serotype-specific antibodies. Only FMDV serotype O virus was isolated from one probang sample. This study shows that the majority of the FMD outbreaks in 2006 in the region studied were caused by FMDV serotype O; however, there was also evidence of antibodies to both SAT 1 and SAT 3 in one outbreak in a herd inside Queen Elizabeth national park area. ©2010 Blackwell Verlag GmbH.
Authors & Co-Authors
Mwiine, Frank Norbert
Uganda, Kampala
Makerere University
Uganda, Kampala
Ministry of Agriculture
Canada, Winnipeg
National Centre for Foreign Animal Disease Ncfad
Ayebazibwe, Chrisostom
Uganda, Kampala
Ministry of Agriculture
Olaho-Mukani, William
Uganda, Kampala
Ministry of Agriculture
Alexandersen, Soren
Denmark, Lyngby
Technical University of Denmark
Balinda, Sheila Nina
Uganda, Kampala
Makerere University
Masembe, Charles
Uganda, Kampala
Makerere University
Ademun Okurut, A. R.
Uganda, Kampala
Ministry of Agriculture
Christensen, Laurids Siig
Denmark, Lyngby
Technical University of Denmark
SØrensen, K. J.
Denmark, Lyngby
Technical University of Denmark
TjØrnehØj, Kirsten
Denmark, Lyngby
Technical University of Denmark
Statistics
Citations: 36
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1111/j.1865-1682.2010.01157.x
ISSN:
18651674
e-ISSN:
18651682
Study Locations
Uganda