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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Prevalence of kidney disease in HIV-infected and uninfected Rwandan Women
PLoS ONE, Volume 6, No. 3, Article e18352, Year 2011
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Description
Background: In the United States, HIV-related kidney disease disproportionately affects individuals of African descent; however, there are few estimates of kidney disease prevalence in Africa. We evaluated the prevalence of kidney disease among HIV-infected and uninfected Rwandan women. Methods: The Rwandan Women's Interassociation Study and Assessment prospectively enrolled 936 women. Associations with estimated glomerular filtration rate (eGFR)<60 mL/min/1.73 m2 and proteinuria were assessed in separate logistic regression models. Results: Among 891 non-pregnant women with available data, 2.4% had an eGFR<60 mL/min/1.73 m2 (calculated by the Modification of Diet in Renal Disease equation, MDRD eGFR) and 8.7% had proteinuria ≥1+. The prevalence of decreased eGFR varied markedly depending on the estimating method used, with the highest prevalence by Cockcroft-Gault. Regardless of the method used to estimate GFR, the proportion with decreased eGFR or proteinuria did not differ significantly between HIV-infected and -uninfected women in unadjusted analysis. After adjusting for age and blood pressure, HIV infection was associated with significantly higher odds of decreased MDRD eGFR but not proteinuria. Conclusion: In a well-characterized cohort of Rwandan women, HIV infection was associated with decreased MDRD eGFR. The prevalence of decreased eGFR among HIV-infected women in our study was lower than that previously reported in African-Americans and in other Central and East African HIV populations, although there was substantial variability depending on the equation used to estimate GFR. Future studies are needed to optimize GFR estimates and to determine the impact of antiretroviral therapy on kidney disease in this population. © 2011 Wyatt et al.
Authors & Co-Authors
Wyatt, Christina M.
United States, New York
Icahn School of Medicine at Mount Sinai
Shi, Qiuhu
United States, Valhalla
New York Medical College
Novak, James E.
United States, Detroit
Henry Ford Health System
Hoover, Donald R.
United States, New Brunswick
Rutgers University–new Brunswick
Szczech, Lynda Anne M.
United States, Durham
Duke University Medical Center
Mugabo, Jules Semahore
United States, Baltimore
University of Maryland, Baltimore Umb
Binagwaho, Agnès
Rwanda, Kigali
Ministry of Health
United States, Boston
Harvard Medical School
Cohen, Mardge H.
United States, Oak Forest
Cook County Bureau of Health Services
Mutimura, Eugene
Rwanda, Kigali
Women's Equity in Access to Care and Treatment
Anastos, Kathryn M.
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Statistics
Citations: 30
Authors: 10
Affiliations: 11
Identifiers
Doi:
10.1371/journal.pone.0018352
e-ISSN:
19326203
Research Areas
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Female