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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Chronic HIV-1 infection frequently fails to protect against superinfection
PLoS Pathogens, Volume 3, No. 11, Year 2007
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Description
Reports of HIV-1 superinfection (re-infection) have demonstrated that the immune response generated against one strain of HIV-1 does not always protect against other strains. However, studies to determine the incidence of HIV-1 superinfection have yielded conflicting results. Furthermore, few studies have attempted to identify superinfection cases occurring more than a year after initial infection, a time when HIV-1-specific immune responses would be most likely to have developed. We screened a cohort of high-risk Kenyan women for HIV-1 superinfection by comparing partial gag and envelope sequences over a 5-y period beginning at primary infection. Among 36 individuals, we detected seven cases of superinfection, including cases in which both viruses belonged to the same HIV-1 subtype, subtype A. In five of these cases, the superinfecting strain was detected in only one of the two genome regions examined, suggesting that recombination frequently occurs following HIV-1 superinfection. In addition, we found that superinfection occurred throughout the course of the first infection: during acute infection in two cases, between 1-2 y after infection in three cases, and as late as 5 y after infection in two cases. Our results indicate that superinfection commonly occurs after the immune response against the initial infection has had time to develop and mature. Implications from HIV-1 superinfection cases, in which natural re-exposure leads to re-infection, will need to be considered in developing strategies for eliciting protective immunity to HIV-1. © 2007 Piantadosi et al.
Authors & Co-Authors
Piantadosi, Anne L.
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Chohan, Bhavna H.
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Chohan, Vrasha
Kenya, Nairobi
University of Nairobi
McClelland, Raymond Scott
Kenya, Nairobi
University of Nairobi
United States, Seattle
University of Washington
Overbaugh, Julie M.
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Statistics
Citations: 144
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1371/journal.ppat.0030177
ISSN:
15537366
e-ISSN:
15537374
Research Areas
Infectious Diseases
Study Design
Cohort Study
Participants Gender
Female