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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The clinical and bacteriogical spectrum of neonatal sepsis in a tertiary hospital in Yaounde, Cameroon
Iranian Journal of Pediatrics, Volume 21, No. 4, Year 2011
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Description
Objective: Sepsis is an important cause of morbidity and mortality in neonates especially in developing countries where identification of the germs and treatment is often unsatisfactory. The aim of the study was to assess the clinical presentation, and bacteriological profile of neonatal infections, and the sensitivity of the causative germs to antibiotics. Methods: We carried out a prospective analytic study in the Yaounde Gynaeco-Obstetric and Pediatric Hospital in Cameroon over a 6 months period from 18th November 2008 to 18th May 2009. On the basis of history and/or clinical findings and paraclinical investigations, 218 neonates out of a total of 628 admissions were investigated and managed for neonatal infection. Findings: The most frequent symptoms were fever (44.95%), refusal to feed/irritability (32.11%), and respiratory distress/cough (28.90%). Premature birth and prolonged rupture of membranes were the most frequent risk factors. Klebsiella spp, Escherichia coli and Enterobacter spp were the most frequent germs identified in respectively 28.6%, 21.4% and 14.3% of the positive samples. Overall sensitivity of the cultures to ampicillin, netilmicin and gentamycin was poor at 29.4%, 31.4% and 18.9% respectively, whereas imipenem, ofloxacin, ciprofloxacin and ceftazidime had the best sensitivities in 91.7%, 90%, 85.3% and 69.4% of the cultures respectively. The mortality rate was 22%, and low birth weight, premature birth and septicemia were significant risk factors for death. Conclusion: Mortality from neonatal sepsis in this context is still high and there is an upsurge of multi-resistant germs to currently used antibiotics, calling for the need for rational use of antibiotics in the management of these infections. © 2011 by Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, All rights reserved.
Authors & Co-Authors
Chiabi, Andréas
Cameroon, Yaounde
Yaounde Gynaeco-obstetric and Pediatric Hospital
Cameroon, Yaounde
Faculty of Medicine and Biomedical Sciences
Djoupomb, Marlene
Cameroon, Bangangté
Institut Supérieur Des Sciences de la Santé
Mah, Evelyne Mungyeh
Cameroon, Yaounde
Yaounde Gynaeco-obstetric and Pediatric Hospital
Cameroon, Yaounde
Faculty of Medicine and Biomedical Sciences
Nguefack, Séraphin
Cameroon, Yaounde
Yaounde Gynaeco-obstetric and Pediatric Hospital
Cameroon, Yaounde
Faculty of Medicine and Biomedical Sciences
Mbuagbaw, Lawrence C.E.
Cameroon, Yaounde
Centre for the Development of Best Practices in Health
Zafack, Joseline Guetsop
Cameroon, Yaounde
Yaounde Gynaeco-obstetric and Pediatric Hospital
Ghoyap, Madeleine
Cameroon, Yaounde
Yaounde Gynaeco-obstetric and Pediatric Hospital
Nkoa, Thérěse
Cameroon, Yaounde
Yaounde Gynaeco-obstetric and Pediatric Hospital
Cameroon
Faculty of Medicine and Biomedical
Tchokoteu, Pouasse Fernand L.
Cameroon, Yaounde
Yaounde Gynaeco-obstetric and Pediatric Hospital
Cameroon, Yaounde
Faculty of Medicine and Biomedical Sciences
Statistics
Citations: 9
Authors: 9
Affiliations: 5
Identifiers
ISSN:
10184406
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Cameroon