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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Determining reinfection rates by hepatitis C testing interval among key populations: A systematic review and meta-analysis
Liver International, Volume 43, No. 12, Year 2023
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Description
Background & Aims: Detecting hepatitis C virus (HCV) reinfection among key populations helps prevent ongoing transmission. This systematic review aims to determine the association between different testing intervals during post-SVR follow-up on the detection of HCV reinfection among highest risk populations. Methods: We searched electronic databases between January 2014 and February 2023 for studies that tested individuals at risk for HCV reinfection at discrete testing intervals and reported HCV reinfection incidence among key populations. Pooled estimates of reinfection incidence were calculated by population and testing frequency using random-effects meta-analysis. Results: Forty-one single-armed observational studies (9453 individuals) were included. Thirty-eight studies (8931 individuals) reported HCV reinfection incidence rate and were included in meta-analyses. The overall pooled estimate of HCV reinfection incidence rate was 4.13 per 100 per person-years (py) (95% confidence interval [CI]: 3.45–4.81). The pooled incidence estimate among people who inject drugs (PWID) was 2.84 per 100 py (95% CI: 2.19–3.50), among men who have sex with men (MSM) 7.37 per 100 py (95% CI: 5.09–9.65) and among people in custodial settings 7.23 per 100 py (95% CI: 2.13–16.59). The pooled incidence estimate for studies reporting a testing interval of ≤6 months (4.26 per 100 py; 95% CI: 2.86–5.65) was higher than studies reporting testing intervals >6 months (5.19 per 100 py; 95% CI: 3.92–6.46). Conclusions: HCV reinfection incidence was highest in studies of MSM and did not appear to change with retesting interval. Shorter testing intervals are likely to identify more reinfections, help prevent onward transmission where treatment is available and enable progress towards global HCV elimination, but additional comparative studies are required. © 2023 The Authors. Liver International published by John Wiley & Sons Ltd.
Authors & Co-Authors
Luhmann, Niklas
Switzerland, Geneva
Organisation Mondiale de la Santé
Baggaley, Rachel Clare
Switzerland, Geneva
Organisation Mondiale de la Santé
MacDonald, Virginia
Switzerland, Geneva
Organisation Mondiale de la Santé
Verster, Annette D.
Switzerland, Geneva
Organisation Mondiale de la Santé
Siegfried, Nandi Louise
South Africa, Cape Town
Independent Clinical Epidemiologist
Conway, Brian
Canada, Burnaby
Simon Fraser University
Klein, Marina Barbara
Canada, Montreal
Mcgill Faculty of Medicine and Health Sciences
Bruneau, Julie
Canada, Montreal
University of Montreal
Stoovè, Mark A.
Australia, Melbourne
Burnet Institute
Hellard, Margaret Elena
Australia, Melbourne
Burnet Institute
Australia, Clayton
Monash University
Doyle, Joseph Samuel
Australia, Melbourne
Burnet Institute
Australia, Clayton
Monash University
Statistics
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1111/liv.15705
ISSN:
14783223
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Systematic review
Participants Gender
Male