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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men
Journal of Clinical Endocrinology and Metabolism, Volume 96, No. 8, Year 2011
Notification
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Description
Context: Kisspeptins stimulate GnRH and thus gonadotropin secretion. Kisspeptin-10 is the minimal kisspeptin sequence with full intrinsic bioactivity, but it has not been studied in man. Objective: We investigated our hypothesis that kisspeptin-10 increases GnRH and thus LH pulse frequency. Design and Participants: The dose response of kisspeptin-10 was investigated by administering iv bolus doses (0.01-3.0 μg/kg) and vehicle to healthy men. Effects on LH pulse frequency and size were determined by deconvolution analysis during infusion of kisspeptin-10 for up to 22.5 h. Results: Intravenous bolus kisspeptin-10 resulted in a rapid and dose-dependent rise in serum LH concentration, with maximal stimulation at 1 μg/kg (4.1 ± 0.4 to 12.4 ± 1.7 IU/liter at 30 min, P < 0.001, n = 6). Administration of 3 μg/kg elicited a reduced response vs. 1 μg/kg (P < 0.05). Infusionof kisspeptin-10 at 4 = g/kg < h for 22.5 h elicited an increase in LH from a mean of 5.4 ± 0.7 to 20.8 ± 4.9 IU/liter (n = 4; P < 0.05) and serum testosterone increased from 16.6 ± 2.4 to 24.0 ± 2.5 nmol/liter(P < 0.001). LH pulses were obscured at this high rate of secretion, but a lower dose infusion of kisspeptin-10 (1.5 μg/kg·h) increased mean LH from 5.2 ± 0.8 to 14.1 ± 1.7 IU/liter (n = 4; P < 0.01)and increased LH pulse frequency from 0.7 ± 0.1 to 1.0 ± 0.2 pulses/h (P < 0.05) and secretory burstmass from 3.9 ± 0.4 to 12.8 ± 2.6 IU/liter (P < 0.05).Conclusions: Kisspeptin-10 boluses potently evoke LH secretion in men, and continuous infusion increases testosterone, LH pulse frequency, and pulse size. Kisspeptin analogues have therapeutic potential as regulators of LH and thus testosterone secretion. Copyright © 2011 by The Endocrine Society.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3380939/bin/supp_96_8_E1228__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3380939/bin/supp_jc.2011-0089_License.pdf
Authors & Co-Authors
George, Jyothis T.
United Kingdom, Edinburgh
Mrc Human Reproductive Sciences Unit
Veldhuis, Johannes D.
United States, Rochester
Mayo Clinic
Roseweir, Antonia Kathryn
United Kingdom, Edinburgh
Mrc Human Reproductive Sciences Unit
Newton, Claire L.
United Kingdom, Edinburgh
Mrc Human Reproductive Sciences Unit
Faccenda, Elena
United Kingdom, Edinburgh
Mrc Human Reproductive Sciences Unit
Millar, Robert P.
United Kingdom, Edinburgh
Mrc Human Reproductive Sciences Unit
South Africa, Cape Town
University of Cape Town
South Africa, Pretoria
University of Pretoria
Anderson, Richard A.A.
United Kingdom, Edinburgh
Mrc Human Reproductive Sciences Unit
United Kingdom, Edinburgh
University of Edinburgh, College of Medicine and Veterinary Medicine
Statistics
Citations: 155
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1210/jc.2011-0089
ISSN:
0021972X
e-ISSN:
19457197
Participants Gender
Male