Penicillium marneffei infection in patients infected with the human immunodeficiency virus: A report of two cases

We present the cytologic and histologic features of two cases of Penicillium marneffei (PM) infection occurring in human immunodeficiency virus-positive patients following a journey to endemic areas, PM closely resembles Histoplasma capsulatum, in both its morphology and tissue reactions. Distinctive histologic features and culture provide the definitive diagnosis. The presence of a PM infection in a human immunodeficiency virus- positive patient returning from an endemic area should be considered an acquired immunodeficiency syndrome-defined illness.