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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Protein alterations in infiltrating ductal carcinomas of the breast as detected by nonequilibrium pH gradient electrophoresis and mass spectrometry
Journal of Biomedicine and Biotechnology, Volume 2008, No. 1, Article 564127, Year 2008
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Description
Improvement of breast-cancer detection through the identification of potential cancer biomarkers is considered as a promising strategy for effective assessment of the disease. The current study has used nonequilibrium pH gradient electrophoresis with subsequent analysis by mass spectrometry to identify protein alterations in invasive ductal carcinomas of the breast from Tunisian women. We have identified multiple protein alterations in tumor tissues that were picked, processed, and unambiguously assigned identities by matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF). The proteins identified span a wide range of functions and are believed to have potential clinical applications as cancer biomarkers. They include glycolytic enzymes, molecular chaperones, cytoskeletal-related proteins, antioxydant enzymes, and immunologic related proteins. Among these proteins, enolase 1, phosphoglycerate kinase 1, deoxyhemoglobin, Mn-superoxyde dismutase, α-B-crystallin, HSP27, Raf kinase inhibitor protein, heterogeneous nuclear ribonucleoprotein A2/B1, cofilin 1, and peptidylprolyl isomerase A were overexpressed in tumors compared with normal tissues. In contrast, the IGHG1 protein, the complement C3 component C3c, which are two newly identified protein markers, were downregulated in IDCA tissues. Copyright © 2008 Maria Kabbage et al.
Authors & Co-Authors
Chouchane, Lotfi
Qatar, Doha
Weill Cornell Medicine-qatar
Kabbage, Maria
Tunisia, Monastir
Faculté de Médecine de Monastir
Chahed, Karim
Tunisia, Monastir
Faculté de Médecine de Monastir
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Hamrita, Bechr
Tunisia, Monastir
Faculté de Médecine de Monastir
Lemaître-Guillier, Christelle
France, Paris
Cnrs Centre National de la Recherche Scientifique
Trimèche, Mounir
Tunisia, Sousse
Hopital Farhat Hached Sousse
Remadi, Sami
Tunisia, Sousse
Laboratoire Cytopath
Hoebeke, Johan
France, Strasbourg
Laboratoire D’immunologie, Immunopathologie et Chimie Thérapeutique I2ct
Statistics
Citations: 29
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1155/2008/564127
ISSN:
11107243
e-ISSN:
11107251
Research Areas
Cancer
Participants Gender
Female