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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Transmission of Kaposi sarcoma-associated herpesvirus between mothers and children in a South African population
Journal of Acquired Immune Deficiency Syndromes, Volume 44, No. 3, Year 2007
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Description
BACKGROUND: To assess whether Kaposi sarcoma-associated herpesvirus (KSHV) with or without HIV coinfection in South African mothers is associated with higher KSHV seropositivity in their children. METHODS: We tested sera from 1287 South African children and 1179 mothers using assays for KSHV lytic K8.1 and latent ORF73 antigens. We computed odds ratios (ORs) and 95% confidence intervals (CIs) to assess associations between KSHV serostatus and risk factors. RESULTS: KSHV seroprevalence was 15.9% (204 of 1287 subjects) in children and 29.7% (350 of 1179 subjects) in mothers. The risk of KSHV seropositivity was significantly higher in children of KSHV-seropositive mothers compared with those of KSHV-seronegative mothers. The HIV status of mothers was marginally associated with an increased risk of KSHV seropositivity in their children (OR = 1.6, 95% CI: 1.0 to 2.6; P = 0.07). KSHV seroprevalence was significantly higher in HIV-infected subjects (P = 0.0005), and HIV-infected subjects had significantly higher lytic and latent KSHV antibody levels than HIV-negative subjects. CONCLUSIONS: The risk of acquisition of KSHV was higher among children of KSHV-seropositive mothers. Although KSHV seroprevalence was significantly higher in children and mothers who were infected with HIV, the HIV status of the mother was only marginally associated with an increased risk of KSHV seropositivity in the child. © 2007 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Malope, Babatyi
South Africa, Johannesburg
National Health Laboratory Service
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Pfeiffer, Ruth M.
United States, Rockville
National Cancer Institute Nci
Mbisa, Georgina L.
United States, Frederick
National Cancer Institute at Frederick
Stein, Lara
South Africa, Johannesburg
National Health Laboratory Service
Ratshikhopha, M. E.
South Africa, Johannesburg
National Health Laboratory Service
O'Connell, Dianne L.
Australia, Woolloomooloo
Cancer Council Nsw
Sitas, F.
South Africa, Johannesburg
National Health Laboratory Service
Australia, Woolloomooloo
Cancer Council Nsw
MacPhail, Andrew Patrick
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Whitby, Denise
United States, Rockville
National Cancer Institute Nci
United States, Frederick
National Cancer Institute at Frederick
United States, Frederick
Saic-frederick
Statistics
Citations: 79
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1097/QAI.0b013e31802f12ea
ISSN:
15254135
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study