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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Bio-monitoring of mycotoxin exposure in Cameroon using a urinary multi-biomarker approach
Food and Chemical Toxicology, Volume 62, Year 2013
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Description
Bio-monitoring of human exposure to mycotoxin has mostly been limited to a few individually measured mycotoxin biomarkers. This study aimed to determine the frequency and level of exposure to multiple mycotoxins in human urine from Cameroonian adults. 175 Urine samples (83% from HIV-positive individuals) and food frequency questionnaire responses were collected from consenting Cameroonians, and analyzed for 15 mycotoxins and relevant metabolites using LC-ESI-MS/MS. In total, eleven analytes were detected individually or in combinations in 110/175 (63%) samples including the biomarkers aflatoxin M1, fumonisin B1, ochratoxin A and total deoxynivalenol. Additionally, important mycotoxins and metabolites thereof, such as fumonisin B2, nivalenol and zearalenone, were determined, some for the first time in urine following dietary exposures. Multi-mycotoxin contamination was common with one HIV-positive individual exposed to five mycotoxins, a severe case of co-exposure that has never been reported in adults before. For the first time in Africa or elsewhere, this study quantified eleven mycotoxin biomarkers and bio-measures in urine from adults. For several mycotoxins estimates indicate that the tolerable daily intake is being exceeded in this study population. Given that many mycotoxins adversely affect the immune system, future studies will examine whether combinations of mycotoxins negatively impact Cameroonian population particularly immune-suppressed individuals. © 2013 Elsevier Ltd.
Authors & Co-Authors
Abia, Wilfred Angie
Cameroon, Yaounde
Université de Yaoundé I
Austria, Tulln
Center for Analytical Chemistry, Tulln
South Africa, Johannesburg
University of Johannesburg
Warth, Benedikt
Austria, Tulln
Center for Analytical Chemistry, Tulln
Sulyok, Michael
Austria, Tulln
Center for Analytical Chemistry, Tulln
Krska, Rudolf
Austria, Tulln
Center for Analytical Chemistry, Tulln
Tchana, Angèle Nkouatchoua
Cameroon, Yaounde
Université de Yaoundé I
Njobeh, Patrick Berka
South Africa, Johannesburg
University of Johannesburg
Turner, Paul Craig
United States, College Park
University of Maryland School of Public Health
Kouanfack, Charles
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Eyongetah, Mbu
Cameroon, Yaounde
Bamenda Regional Hospital
Dutton, Michael Francis
South Africa, Johannesburg
University of Johannesburg
Moundipa, Paul Fewou
Cameroon, Yaounde
Université de Yaoundé I
Statistics
Citations: 114
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1016/j.fct.2013.10.003
ISSN:
02786915
e-ISSN:
18736351
Research Areas
Food Security
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Cameroon