Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Outcome of octogenarians with atrial fibrillation undergoing percutaneous coronary intervention: insights from the AFCAS registry
Clinical Cardiology, Volume 40, No. 12, Year 2017
Notification
URL copied to clipboard!
Description
Background: More evidence is needed on the optimal antithrombotic regimen in elderly patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI). Hypothesis: Octogenarian patients (aged ≥80 years) with AF who underwent PCI have worse 12-month clinical outcome, compared with younger patients. Methods: We performed a post-hoc analysis of data from the prospective, multicenter AFCAS registry, which enrolled consecutive patients with AF who underwent PCI and stenting. Outcome measures included major adverse cardiac/cerebrovascular events (MACCE; all-cause death, myocardial infarction, repeat revascularization, stent thrombosis, or stroke/transient ischemic attack) and bleeding events at 12-month follow-up. Results: Out of 925 AF patients enrolled in AFCAS registry, 195 (21.1%) were ≥80 years. Mean age was 82.9 ± 2.6 years; 41.5% were women; 32.3% had diabetes mellitus. Compared with patients aged <80 years, there were more females among the octogenarians (P < 0.001). Compared with younger patients, octogenarians smoked and had dyslipidemia less often, and presented more frequently with acute coronary syndrome. The frequency and duration of antithrombotic regimens prescribed at discharge were comparable. At 12-month follow-up, overall MACCE rate was higher in octogenarians compared with younger patients (27.7% vs 20.1%, P = 0.02). The rate of acute myocardial infarction was higher in octogenarians (9.2% vs 4.9%, P = 0.02), but the rates of all bleeds and BARC >2 bleeds were similar (P = 0.13, P = 0.29, respectively). Conclusions: In real-world patients with AF undergoing PCI, patients aged ≥80 years had higher incidence of MACCE at 12-month follow-up compared with younger patients, although they received comparable antithrombotic treatment. The rates of bleeding events were similar. © 2017 Wiley Periodicals, Inc.
Authors & Co-Authors
Nammas, Wail M.
Finland, Pori
Satakunta Central Hospital
Schlitt, Axel
Germany, Halle
Martin-luther-universität Halle-wittenberg
Rubboli, Andrea
Italy, Bologna
Ospedale Maggiore
Karjalainen, Pasi Paavo
Finland, Pori
Satakunta Central Hospital
Proietti, Marco
United Kingdom, Birmingham
Birmingham City Hospital
Lip, Gregory Y.H.
United Kingdom, Birmingham
Birmingham City Hospital
Denmark, Aalborg
Aalborg University
Airaksinen, Juhani K.E.
Finland, Turku
Turun Yliopisto
Statistics
Citations: 2
Authors: 7
Affiliations: 7
Identifiers
Doi:
10.1002/clc.22821
ISSN:
01609289
Research Areas
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cohort Study
Participants Gender
Female