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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Circulating heat shock protein 70 (Hsp70) in elderly members of a rural population from Cameroon: Association with infection and nutrition
Archives of Gerontology and Geriatrics, Volume 53, No. 3, Year 2011
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Description
Hsp are highly conserved cytoprotective proteins which have been repeatedly portrayed at elevated levels in various infectious diseases, and there are suggestions that the presence of infectious agents may possibly be the root cause of Hsp induction. As organisms age the vulnerability to illnesses such as infection and inflammation increases and late complications due to infectious agents are mostly observed in the older part of the population. Although it is well known that environmental conditions can modulate the susceptibility to infection, and that poor nutritional status can increase the risk of contracting infection when exposed to an infectious agent, the effects of environmental conditions and nutritional status on the heat shock response have not been investigated. Therefore, we studied the heat shock response in a special elderly population living in a remote area in Cameroon, where infection and parasitosis are endemic. Our results indicate a significant increase in Hsp70 serum levels with increasing degree of inflammation. We found negative correlations between Hsp70 levels and micronutrients including vitamin D, vitamin B 12, as well as folate, which could be linked to the immune modulating effects of these vitamins. © 2011 Elsevier Ireland Ltd.
Authors & Co-Authors
Njemini, Rose
Belgium, Jette
Faculteit Geneeskunde en Farmacie
Smitz, J. E.J.
Belgium, Jette
Universitair Ziekenhuis Brussel
Demanet, Christian G.
Belgium, Jette
Universitair Ziekenhuis Brussel
Sosso, Maurice Aurélien
Cameroon, Yaounde
Université de Yaoundé I
Mets, Tony F.
Belgium, Jette
Faculteit Geneeskunde en Farmacie
Belgium, Jette
Universitair Ziekenhuis Brussel
Statistics
Citations: 19
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.archger.2011.01.005
ISSN:
01674943
e-ISSN:
18726976
Research Areas
Food Security
Study Design
Cross Sectional Study
Study Locations
Cameroon