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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Reference values of lymphocyte subsets in healthy, HIV-negative children in Cameroon
Clinical and Vaccine Immunology, Volume 18, No. 5, Year 2011
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Description
Lymphocyte subset reference values used to monitor infectious diseases, including HIV/AIDS, tuberculosis, malaria, or other immunological disorders in healthy children in Cameroon, are lacking. Values for Caucasian cohorts are already being utilized for clinical decisions but could be inappropriate for African populations. We report here the immunological profile for children aged from birth through 6 years in Cameroon and also compare our values to data from other African and Caucasian populations. In a cohort of 352 healthy children, aged 0 to 6 years, the relative and absolute numbers of T-cell subsets, B cells, and NK lymphocytes were determined from peripheral blood collected in EDTA tubes. Samples were stained with BD Multitest reagents in Trucount tubes and analyzed by using CellQuest-Pro and FlowJo software. We evaluated about 23 different lymphocyte subsets in which the absolute number and percentage values differed significantly (P < 0.05) with age and peaked between 6 and 12 months. B-cell values were higher compared to reported values from developed countries. Differences in activated and differentiated T cells were observed in subjects between 1 and 6 years of age. The absolute CD8+ T-cell count and the CD4+/CD8+ ratio seem to depend on gender. Normal lymphocyte subsets values among children from Cameroon differ from reported values in Caucasian and some African populations. The differences observed could be due to genetic and environmental factors coupled with the methodology used. These values could be used as initial national reference guidelines as more data are assembled. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Sagnia, Bertrand
Cameroon
Chantal Biya Intl. Reference Centre for Research on Hiv/aids Prevention and Management Circb
Ndongo, Francis Ateba
Cameroon, Yaounde
Mother-child Hospital of Chantal Biya Foundation
Tetang, Suzie Ndiang Moyo
Cameroon
Chantal Biya Intl. Reference Centre for Research on Hiv/aids Prevention and Management Circb
Torimiro, Judith Ndongo
Cameroon
Chantal Biya Intl. Reference Centre for Research on Hiv/aids Prevention and Management Circb
Cairo, Cristiana
United States, Baltimore
Institute of Human Virology
Domkam, Irénée Kammogne
Cameroon
Chantal Biya Intl. Reference Centre for Research on Hiv/aids Prevention and Management Circb
Agbor, Geraldine
Cameroon
Chantal Biya Intl. Reference Centre for Research on Hiv/aids Prevention and Management Circb
Mve, Emmanuel
Cameroon
Chantal Biya Intl. Reference Centre for Research on Hiv/aids Prevention and Management Circb
Tocke, Olive
Cameroon, Yaounde
Hôpital de District de la Cité Verte
Fouda, Emilien
Cameroon, Yaounde
Hôpital de District de la Cité Verte
Ouwe-Missi-Oukem-Boyer, Odile N.
Cameroon
Chantal Biya Intl. Reference Centre for Research on Hiv/aids Prevention and Management Circb
Colizzi, Vittorio C.
Cameroon
Chantal Biya Intl. Reference Centre for Research on Hiv/aids Prevention and Management Circb
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Statistics
Citations: 35
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1128/CVI.00483-10
ISSN:
15566811
e-ISSN:
1556679X
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Cameroon