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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
arts and humanities
A benign form of neuromyelitis optica does it exist?
Archives of Neurology, Volume 68, No. 7, Year 2011
Notification
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Description
Background: Few data exist on a possible benign form of neuromyelitis optica (NMO). Objectives: To identify NMO with a good outcome (go-NMO) among a large population of patients and to describe demographic and clinical variables associated with go-NMO vs standard NMO and benign multiple sclerosis. Design: Observational retrospective multicenter study. Setting: Twenty-five medical centers in metropolitan France (MF) and 3 medical centers in the French West Indies (FWI). Patients: A total of 175 patients with NMO were retrospectively analyzed from 2 cohorts: 125 in MF and 50 patients of nonwhite race/ethnicity in the FWI. Patients in MF fulfilled the 2006 NMO criteria, whereas patients in the FWI fulfilled the 1999 or 2006 NMO criteria. Neuromyelitis optica and multiple sclerosis databases were reviewed, and patients with a score of 3 or lower on the Expanded Disability Status Scale after a 10-year follow-up period were considered to have go-NMO. Main Outcome Measures: Clinical, laboratory, and magnetic resonance imaging data and course of disability. Results: In MF, go-NMO was observed in 11 patients, including 3 untreated patients. In the FWI, NMO was severe because of disability related to optic neuritis. Compared with standard NMO, go-NMO was associated with a lower annualized relapse rate (0.3 vs 1.0, P<.01), and 8 of 11 patients with go-NMO showed complete regression of myelitis on magnetic resonance imaging during the disease course. Three patients experienced a disabling attack of NMO after 15 years of follow-up. A good outcome occurred less frequently among patients with NMO than among patients with multiple sclerosis (12.0% vs 22.4%, P=.03). Conclusions: Among patients in MF, go-NMO occurs rarely. However, because a disabling attack may occur after a long follow-up period, a benign form of NMO cannot be defined. ©2011 American Medical Association. All rights reserved.
Authors & Co-Authors
Cabre, Philippe
Unknown Affiliation
Marignier, Romain
France, Lyon
Hopital Neurologique et Neurochirurgical Pierre Wertheimer
Zéphir, Hélène
France, Lille
Chu Lille
Papeix, Caroline
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Audoin, Bertrand
France, Marseille
Centre de Résonance Magnétique Biologique et Médicale
Lebrun-Frénay, Christine
France, Nice
Centre Hospitalier Universitaire de Nice
Pelletier, Jean B.
France, Marseille
Centre de Résonance Magnétique Biologique et Médicale
Fontaine, Bertrand
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Vermersch, P.
France, Lille
Chu Lille
Confavreux, Christian
France, Lyon
Hopital Neurologique et Neurochirurgical Pierre Wertheimer
de Sèze, Jéróme
France, Strasbourg
Centre D'investigation Clinique de Strasbourg
Brochet, Bruno
Unknown Affiliation
Camdessanché, Jean Philippe
Unknown Affiliation
Camu, William
Unknown Affiliation
Casez, Olivier
Unknown Affiliation
Castelnovo, Giovanni
Unknown Affiliation
Clavelou, Pierre
Unknown Affiliation
Cotton, François
Unknown Affiliation
Créange, Alain
Unknown Affiliation
Defer, Gilles Louis
Unknown Affiliation
Debouverie, Marc
Unknown Affiliation
Edan, G.
Unknown Affiliation
Gout, Olivier F.
Unknown Affiliation
Jousserand, Guillemette
Unknown Affiliation
Labauge, Pierre M.
Unknown Affiliation
Laplaud, David Axel
Unknown Affiliation
Moreau, Thibault
Unknown Affiliation
Stankoff, Bruno
Unknown Affiliation
Tourbah, Ayman
Unknown Affiliation
Vukusic, Sandra
Unknown Affiliation
Grimaud, Jérôme
Unknown Affiliation
Hautecoeur, Patrick
Unknown Affiliation
Heinzlef, Olivier
Unknown Affiliation
Seeldrayers, Pierrette A.
Unknown Affiliation
Slassi, Ilham
Unknown Affiliation
Statistics
Citations: 54
Authors: 35
Affiliations: 6
Identifiers
Doi:
10.1001/archneurol.2011.127
ISSN:
00039942
Research Areas
Cancer
Disability
Study Design
Cross Sectional Study
Cohort Study