Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Histidine-rich protein 2 plasma levels predict progression to cerebral malaria in malawian children with plasmodium falciparum infection
Journal of Infectious Diseases, Volume 208, No. 3, Year 2013
Notification
URL copied to clipboard!
Description
Some children with uncomplicated malaria progress to cerebral malaria despite appropriate treatment; identifying them in advance might improve their care. The objective of this study was to determine if plasma concentrations of a malaria protein, HRP2 (histidine-rich protein 2) would serve this purpose. Cases and controls were children presenting with uncomplicated malaria; the cases (n = 25) developed cerebral malaria, and the controls (n = 125) did not. Mean plasma HRP2 concentrations were significantly higher in the cases, and an HRP2 cutoff was identified that could predict disease progression (sensitivity and specificity, 88% for each). Quantitative measurements of HRP2 may be a useful screening tool. © 2013 The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3699003/bin/supp_208_3_500__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3699003/bin/supp_jit176_jit176supp.docx
Authors & Co-Authors
Fox, Lindsay L.
United States, East Lansing
Msu College of Osteopathic Medicine
Malawi, Zomba
University of Malawi
Taylor, Terrie Ellen
United States, East Lansing
Msu College of Osteopathic Medicine
Malawi, Zomba
University of Malawi
Pensulo, Paul
Malawi, Zomba
University of Malawi
Liomba, Alice Wangui
Malawi, Zomba
University of Malawi
Mpakiza, Ashley
Malawi, Zomba
University of Malawi
Varela, Amanda
Malawi, Zomba
University of Malawi
Glover, Simon J.
Malawi, Zomba
University of Malawi
Reeves, Mathew J.
United States, East Lansing
Michigan State University
Seydel, Karl B.
United States, East Lansing
Msu College of Osteopathic Medicine
Malawi, Zomba
University of Malawi
Statistics
Citations: 50
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1093/infdis/jit176
ISSN:
00221899
Research Areas
Infectious Diseases
Maternal And Child Health
Study Approach
Quantitative