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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
T-helper 17 cells are associated with pathology in human schistosomiasis
Journal of Infectious Diseases, Volume 207, No. 1, Year 2013
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Description
Background. Schistosome infections are often clinically silent, but some individuals develop severe pathological reactions. In several disease processes, T-helper 17 (Th17) cells have been linked to tissue injuries, while regulatory T cells (Tregs) are thought to downmodulate inflammatory reactions. We assessed whether bladder pathology in human Schistosoma haematobium infection is related to the balance of Th17 cells and Tregs. We used a murine model of Schistosoma mansoni infection to further investigate whether the peripheral profiles reflected ongoing events in tissues. Methods. We characterized T-helper cell subsets in the peripheral blood of children residing in a S. haematobium- endemic area and in the peripheral blood, spleen, and hepatic granulomas of S. mansoni-infected highpathology CBA mice and low-pathology C57BL/6 mice. Results. S. haematobium-infected children with bladder pathology had a significantly higher percentage of Th17 cells than those without pathology. Moreover, the Th17/Treg ratios were significantly higher in infected children with pathology, compared with infected children without pathology. Percentages of interleukin 17-producing cells were significantly higher in spleen and granulomas of CBA mice, compared with C57BL/6 mice. This difference was also reflected in the peripheral blood. Conclusions. This is the first study to indicate that Th17 cells may be involved in the pathogenesis of human schistosomiasis. © The Author 2012.
Authors & Co-Authors
Mbow, Moustapha
Senegal, Dakar
Le Dantec University Teaching Hospital
Netherlands, Leiden
Leids Universitair Medisch Centrum
Belgium
Institute of Tropical Medicine of Antwerp
Larkin, Bridget M.
United States, Boston
Tufts University School of Medicine
Meurs, Lynn
Belgium
Institute of Tropical Medicine of Antwerp
Wammes, Linda Judith
Netherlands, Leiden
Leids Universitair Medisch Centrum
De Jong, Sanne E.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Labuda, Lucja A.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Camara, Makhtar T.
Senegal, Dakar
Le Dantec University Teaching Hospital
Smits, Hermelijn Helene
Netherlands, Leiden
Leids Universitair Medisch Centrum
Polman, Katja
Belgium
Institute of Tropical Medicine of Antwerp
Diéye, Tandakha Ndiaye D.
Senegal, Dakar
Le Dantec University Teaching Hospital
Mboup, Souleymane
Senegal, Dakar
Le Dantec University Teaching Hospital
Stadecker, Miguel J.
United States, Boston
Tufts University School of Medicine
Yazdanbakhsh, Maria M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Statistics
Citations: 86
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.1093/infdis/jis654
ISSN:
00221899
Research Areas
Infectious Diseases
Maternal And Child Health
Violence And Injury