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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Bioactive properties of plant species ingested by chimpanzees (Pan troglodytes schweinfurthii) in the Kibale National Park, Uganda
American Journal of Primatology, Volume 68, No. 1, Year 2006
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Description
We measured the biological activities of a selected sample (84 crude extracts) of 24 species eaten by wild chimpanzees (Pan troglodytes schweinfurthii) in the Kibale National Park, western Uganda, to assess their potential chemotherapeutic values. Antibacterial, antimalarial, and/ or antileishmania activities were observed in some crude extracts, and five of these extracts showed a significant cytotoxicity against human tumor cells. Active compounds isolated from three plant parts occasionally ingested by chimpanzees (Diospyros abyssinica (Ebenaceae) bark, Uvariopsis congensis (Annonaceae) leaves, and Trichilia rubescens (Meliaceae) leaves) showed highly significant medicinal properties. Two novel antiparasitic limonoids were isolated from Trichilia rubescens and their molecular structures were determined. In addition to elucidating the natural equilibrium maintained between hosts and pathogens, our investigation of the diet of wild chimpanzees may serve as a guideline to discovering plants with bioactive properties that should be preserved from destruction because of their health maintenance value for great ape populations. © 2006 Wiley-Liss, Inc.
Authors & Co-Authors
Krief, Sabrina
France, Gif-sur-yvette
Institut de Chimie Des Substances Naturelles
France, Paris
Éco-anthropologie
Huffman, Michael A.
Japan, Kyoto
Kyoto University
Sevénet, Thiérry
France, Gif-sur-yvette
Institut de Chimie Des Substances Naturelles
Hladik, Claude Marcel
France, Paris
Éco-anthropologie
Gréllier, Philippe
France, Paris
Museum National D'histoire Naturelle
Loiseau, Philippe Marie
France, Gif-sur-yvette
Université Paris-saclay
Wrangham, Richard W.
United States, Salem
Peabody Essex Museum
Statistics
Citations: 61
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1002/ajp.20206
ISSN:
02752565
Research Areas
Cancer
Study Locations
Uganda