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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Relative prevalence and risk factors of HTLV-I and HTLV-II infection in US blood donors
The Lancet, Volume 337, No. 8755, Year 1991
Notification
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Description
The clinical significance of human T-cell lymphotropic virus type II (HTLV-II) infection, unlike that of HTLV-I, is unknown, and the major known association of HTLV-II seropositivity is with intravenous drug abuse. Screening of blood donors for HTLV-I, now routine in North America, does not distinguish this retrovirus from HTLV-II. To find out more about the seroepidemiology of and risk factors for HTLV I and II, blood from 480 000 volunteer donors in five geographically separate US urban centres was tested for antibodies to HTLV-I/II and HIV-1. Confirmed HTLV-I/II seropositive donors were then followed up by DNA amplification to distinguish type I from type II and by interviews focusing on possible risk factors. HTLV seroprevalence was 3·3 times greater than that for HIV-1 (0·043% vs 0·013%). DNA amplification on 65 of the 207 HTLV-I/II seropositive donors revealed that 34 (52%) had HTLV-II infection and 28 (43% had HTLV-I; 3 samples were uninformative. Interviews of 49 donors showed that whereas HTLV-I was principally associated with donor origin from endemic regions, the major risk factor for HTLV-II infection was intravenous drug use. The surprisingly high rate of HTLV-II infection in US blood donors raises important public health and donor counselling issues since HTLV-I infection is associated with adult T-cell leukaemia and a neurological disorder while the pathogenicity of HTLV-II is as yet unclear. © 1991.
Authors & Co-Authors
Lee, H.
United States, Chicago
Abbott Laboratories
Swanson, Priscilla A.
United States, Chicago
Abbott Laboratories
Rosenblatt, J. D.
United States, Los Angeles
David Geffen School of Medicine at Ucla
Chen, Irving S.Yu
United States, Los Angeles
David Geffen School of Medicine at Ucla
Sherwood, W. C.
South Africa, Philadelphia
Penn-jersey Regional Blood Services
Smith, D. E.
United States, New Orleans
Blood Center for Southeast Louisiana
Tegtmeier, Gary E.
United Kingdom
Community Blood Center of Greater Kansas City
Fernando, L. P.
United Kingdom
Sacramento Medical Foundation Blood Center
Fang, Chyang Tzong
United States, Rockville
Holland Laboratory for Biomedical Sciences
Osame, M.
Japan, Kagoshima
Kagoshima University
Kleinman, Steven H.
United States, Los Angeles
Los Angeles-orange Counties Red Cross Blood Services
Statistics
Citations: 117
Authors: 11
Affiliations: 9
Identifiers
Doi:
10.1016/0140-6736(91)93126-T
ISSN:
01406736
Research Areas
Genetics And Genomics
Infectious Diseases
Substance Abuse
Study Design
Cross Sectional Study