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immunology and microbiology

Induction of Th1 cytokine responses by mycobacterial antigens in leprosy

Infection and Immunity, Volume 64, No. 10, Year 1996

Twelve mycobacterial antigens were compared for induction of gamma interferon (IFN-γ) secretion by human blood mononuclear cells of patients with leprosy. Fractionated Mycobacterium leprae antigens containing cell wall proteins or cytosolic and membrane proteins induced good IFN-γ responses in tuberculoid leprosy patients. Lipoarabinomannan from M. tuberculosis Erdman and M. leprae mycolylarabinogalactan peptidoglycan were the poorest IFN-γ inducers.

Statistics
Citations: 33
Authors: 8
Affiliations: 4
Identifiers
Doi: 10.1128/iai.64.10.4385-4389.1996
ISSN: 00199567

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