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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Multitissue insulin resistance despite near-normoglycemic remission in Africans with ketosis-prone diabetes
Diabetes Care, Volume 31, No. 12, Year 2008
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Description
OBJECTIVE - To characterize insulin action in Africans with ketosis-prone diabetes (KPD) during remission. RESEARCH DESIGN AND METHODS - At Saint-Louis Hospital, Paris, France, 15 African patients with KPD with an average 10.5-month insulin-free near-normoglycemic remission period (mean A1C 6.2%) were compared with 17 control subjects matched for age, sex, BMI, and geographical origin. Insulin stimulation of glucose disposal, and insulin suppression of endogenous glucose production (EGP) and nonesterified fatty acids (NEFAs), was studied using a 200-min two-step (10 mU · m -2 body surface · min -1 and 80 mU · m -2 · min -1 insulin infusion rates) euglycemic clamp with [6,6 -2H 2]glucose as the tracer. Early-phase insulin secretion was determined during an oral glucose tolerance test. RESULTS - The total glucose disposal was reduced in patients compared with control sub- jects(7.5 ± 0.8 [mean ± SE] vs. 10.5 ± 0.9 mg · kg -1 · min -1; P = 0.018). EGP rate was higher in patients than control subjects at baseline (4.0 ± 0.3 vs. 3.0 ± 0.1 mg · kg -1 · min -1:; P = 0.001) and after 200-min insulin infusion (10 mU · m -2 · min -1: 1.6 ± 0.2 vs. 0.6 ± 0.1, P = 0.004; 80 mU · m -2 · min -1: 0.3 ± 0.1 vs. 0mg · kg -1 · min -1, P = 0.007). Basal plasma NEFA concentrations were also higher in patients (1,936.7 ± 161.4 vs. 1,230.0 ± 174.1 μmol/l; P = 0.002) and remained higher after 100-min 10 mU · m -2 · min -1 insulin infusion (706.6 ± 96.5 vs. 381.6 ± 55.9 μmol/l; P = 0.015). CONCLUSIONS - The triad hepatic, adipose tissue, and skeletal muscle insulin resistance is observed in patients with KPD during near-normoglycemic remission, suggesting that KPD is a form of type 2 diabetes. © 2008 by the American Diabetes Association.
Authors & Co-Authors
Choukem, Siméon Pierre
France, Paris
Université Paris Cité
France, Paris
Hôpital Saint-louis
Sobngwi, Eugène
France, Paris
Université Paris Cité
France, Paris
Hôpital Saint-louis
United Kingdom, Newcastle
Newcastle University
Fetita, Lila Sabrina
France, Paris
Université Paris Cité
Boudou, Philippe
France, Paris
Université Paris Cité
France, Paris
Centre de Recherche Des Cordeliers
Boirie, Yves
France, Saint-genes-champanelle
Unité de Nutrition Humaine Unh
Hainault, Isabelle A.
France, Paris
Centre de Recherche Des Cordeliers
Vexiau, Patrick
France, Paris
Université Paris Cité
Mauvais-Jarvis, Franck
United States, Evanston
Northwestern University
Calvo, Fabien
France, Paris
Hôpital Saint-louis
Gautier, Jean François
France, Paris
Université Paris Cité
France, Paris
Hôpital Saint-louis
France, Paris
Centre de Recherche Des Cordeliers
Statistics
Citations: 27
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.2337/dc08-0914
ISSN:
19355548
Research Areas
Health System And Policy
Noncommunicable Diseases