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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Visceral leishmaniasis. Persistence of parasites in lymph nodes after clinical cure
Journal of Infection, Volume 47, No. 1, Year 2003
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Description
Visceral leishmaniasis (VL) is generally associated with severe immunodeficiency (AIDS; renal, liver, and heart transplantations; haemopoietic malignancies). More rarely it can be related to an immunotolerence status such as pregnancy. Various observations report the development of leishmaniasis several months or even years after exposure to the parasite. Relapses occur rarely in patients not known to be immunocompromised, but are common after incomplete treatment. They are frequent in patients with Leishmania/HIV co-infection. Asymptomatic phases and relapses suggest that parasite can exist in the tissues for a long time before and/or after clinical onset of the disease. The mechanisms of onset of clinical leishmaniasis following exposure and infestation are highly relevant to understanding the pathology of the disease. The survival of Leishmania parasite between infection and disease or after cure is a very important issue for clinicians and epidemiologists. We describe two cases of VL occurring in a patient with lymphoma and in a pregnant woman. In both cases, parasites remained present in the lymph nodes after clinical cure. © 2003 The British Infection Society. Published by Elsevier Science Ltd. All rights reserved.
Authors & Co-Authors
Dereure, Jacques
France, Montpellier
Université de Montpellier
Cartron, Guillaume
France, Tours
Centre Hospitalier Regional et Universitaire de Tours
Richard-Lenoble, Dominique
France, Tours
Centre Hospitalier Regional et Universitaire de Tours
Dedet, Jean Pierre
France, Montpellier
Université de Montpellier
Statistics
Citations: 51
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/S0163-4453(03)00002-1
ISSN:
01634453
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Participants Gender
Female