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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Performance of spirometry assessment at TB diagnosis
International Journal of Tuberculosis and Lung Disease, Volume 27, No. 11, Year 2023
Notification
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Description
BACKGROUND: Spirometry is considered relevant for the diagnosis and monitoring of post-TB lung disease. However, spirometry is rarely done in newly diagnosed TB patients. METHODS : Newly diagnosed, microbiologically confirmed TB patients were recruited for the study. Spirometry was performed within 21 days of TB treatment initiation according to American Thoracic Society/ European Respiratory Society guidelines. Spirometry analysis was done using Global Lung Initiative equations for standardisation. RESUL T S : Of 1,430 eligible study participants, 24.7% (353/1,430) had no spirometry performed mainly due to contraindications and 23.0% (329/1,430) had invalid results; 52.3% (748/1,430) of participants had a valid result, 82.8% (619/748) of whom had abnormal spirometry. Of participants with abnormal spirometry, 70% (436/619) had low forced vital capacity (FVC), 6.1% (38/619) had a low ratio of forced expiratory volume in 1 sec (FEV1) to FVC, and 19.1% (118/619) had low FVC, as well as low FEV1/FVC ratio. Among those with abnormal spirometry, 26.3% (163/619) had severe lung impairment. CONCLUS IONS: In this population, a high proportion of not performed and invalid spirometry assessments was observed; this was addressed by removing tachycardia as a (relative) contraindication from the study guidance and retraining. The high proportion of patients with severe pulmonary impairment at the time of TB diagnosis suggests a huge morbidity burden and calls for further longitudinal studies on the relevance of spirometry in predicting chronic lung impairment after TB. © 2023 The Union.
Authors & Co-Authors
Rachow, Andrea
Germany, Munich
Ludwig-maximilians-universität München
Ivanova, Olena
Germany, Munich
Ludwig-maximilians-universität München
Bakuli, Abhishek
Germany, Munich
Ludwig-maximilians-universität München
Khosa, Celso
Mozambique, Marracuene
Instituto Nacional de Saúde
Nhassengo, Pedroso
Mozambique, Marracuene
Instituto Nacional de Saúde
Owolabi, Olumuyiwa A.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Jayasooriya, Shamanthi Maya
United Kingdom, London
London School of Hygiene & Tropical Medicine
Ntinginya, Nyanda Elias
Tanzania, Tanga
National Institute for Medical Research Tanga
Sabi, Issa
Tanzania, Tanga
National Institute for Medical Research Tanga
Rassool, Mohammed Siddique
South Africa, Johannesburg
University of the Witwatersrand
Bennet, Jaclyn Ann
South Africa, Johannesburg
University of the Witwatersrand
Niemann, Stefan
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Mekota, Anna Maria
Germany, Munich
Ludwig-maximilians-universität München
Allwood, Brian William
South Africa, Stellenbosch
Stellenbosch University
Wallis, Robert S.
South Africa, Johannesburg
The Aurum Institute
Charalambous, Salome
South Africa, Johannesburg
The Aurum Institute
United States, Nashville
Vanderbilt University
Höelscher, Michael
Germany, Munich
Ludwig-maximilians-universität München
Churchyard, Gavin John
South Africa, Johannesburg
The Aurum Institute
United States, Nashville
Vanderbilt University
Statistics
Authors: 18
Affiliations: 9
Identifiers
Doi:
10.5588/ijtld.23.0040
ISSN:
10273719
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study