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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Distribution and heterogeneity of hepatitis C genotypes in hepatitis patients in Cameroon
Journal of Medical Virology, Volume 77, No. 3, Year 2005
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Description
Hepatitis C virus infects humans world-wide. The virus genome varies greatly and it has several genotypes. HCV infection is highly prevalent in Central Africa and Cameroon. Initial studies on the genetic variability of HCV showed infection with HCV genotypes 1, 2, and 4. We have now sequenced the NS5b and E2 regions of 156 HCV isolates collected from patients presenting for diagnosis in Yaounde and used the data to describe the distribution of HCV genotypes and subtypes in patients with hepatitis in Cameroon. Genotype 1 was more frequent than Genotypes 4 and 2. Genotypes 1 and 4 were highly heterogeneous, containing many subtypes described previously (1b, 1c, 1e, 1h, 1l, 4f, 4t, 4p, 4k) and unsubtyped groups. There was a systematic phylogenetic concordance between NS5b and E2 sequence clustering. The Genotype 2 sequences did not vary. Neither subject age nor gender influenced HCV distribution. HCV Genotypes 1 and 4 are very heterogeneous in Cameroon, perhaps due to ancient infections. The homogeneity of HCV Genotype 2 indicates its more recent introduction from western Africa. © 2005 Wiley-Liss, Inc.
Authors & Co-Authors
Pasquier, Christophe J.M.
France, Toulouse
Hôpital Purpan
Njouom, Richard
Cameroon, Yaounde
Centre Pasteur du Cameroun
Ayouba, Ahidjo
Cameroon, Yaounde
Centre Pasteur du Cameroun
Dubois, Martine
France, Toulouse
Hôpital Purpan
Sartre, Michèle Tagni
Cameroon, Yaounde
Société Camerounaise de Gastroenterologie
Vessiére, Aurélia
Cameroon, Yaounde
Centre Pasteur du Cameroun
Timba, Isabelle
Cameroon, Yaounde
Société Camerounaise de Gastroenterologie
Thonnon, Jocelyn
Cameroon, Yaounde
Centre Pasteur du Cameroun
Izopet, Jacques
France, Toulouse
Hôpital Purpan
Nerrienet, Eric
Cameroon, Yaounde
Centre Pasteur du Cameroun
Statistics
Citations: 57
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1002/jmv.20468
ISSN:
01466615
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Cameroon