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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Reassessment of childhood B-lineage lymphoblastic leukemia karyotypes using spectral analysis
Genes Chromosomes and Cancer, Volume 30, No. 4, Year 2001
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Description
We studied a stratified cohort of 51 childhood B-lineage acute lymphoblastic leukemias (B-ALLs) to evaluate the efficiency of spectral karyotyping (SKY) in the detection of chromosome aberrations previously diagnosed using chromosome banding and/or reverse transcriptase polymerase chain reaction. Despite the small number of cases analyzed, several important features emerge from the study: (a) The result of banding analysis was revised in two-thirds of the cases. Eighty-three chromosome anomalies previously undetected or not characterized using chromosome banding were identified by spectral karyotyping, even in patients with apparently normal karyotypes. (b) All hyperdiploidy cases showed one or more extra copies of chromosomes X, 14, and 21. (c) Two hidden rearrangements, a t(7;12)(?p12;p13), and a new translocation, a t(9;12)(q31;p13), both involving the TEL gene, were characterized. (d) Some cryptic rearrangements, such as the der(21) t(12;21) translocation, remained undetected. (e) No new recurrent chromosome anomalies were discovered with this technique. In conclusion, the present study confirms the efficiency of the SKY technique in resolving and characterizing many complex chromosome anomalies seen in childhood B-ALLs, but it raises questions about the ability of this technique to detect cryptic rearrangements, such as the t(12;21) translocation. © 2001 Wiley-Liss. Inc.
Authors & Co-Authors
Elghèzal, Hatem M.
France, Paris
Hôpital Necker Enfants Malades
Pérot, Christine
France, Paris
Hôpital Saint-antoine
Eydoux, Patrice
France, Paris
Hôpital Robert-debré Ap-hp
Vekemans, Michel J.J.
France, Paris
Hôpital Necker Enfants Malades
Romana, Serge Pierrick
France, Paris
Hôpital Necker Enfants Malades
Statistics
Citations: 31
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1002/gcc.1104
ISSN:
10452257
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Cohort Study