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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Pharmacokinetics of tobramycin in the camel
Journal of Veterinary Pharmacology and Therapeutics, Volume 17, No. 1, Year 1994
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Description
A/Hadi, A.A., Wasfi, I.A., Gadir, F.A., Amiri, M.H., Bashir, A.K. Baggot, J.D. Pharmacokinetics of tobramycin in the camel. J. vet. Pharmacol. Therap. 17. 48–51. The pharmacokinetics of tobramycin were determined in six healthy camelsCamelus dromedarius following the intravenous (i.v.) and intramuscular (i.m. administration of single doses of tobramycin sulphate (40 mg/ml). The half‐life to tobramycin was 189 ± 21 min and the mean residence time was 254 ± 26 min. The apparent volume of distribution (area method) was 245 ± 21 ml/kg. while volume of the central compartment of the two‐compartment pharmaco‐kinetic model was 110 ± 12 ml/kg. The clearance (systemic) of tobramycin was 0.90 ± 0.10 ml/min/kg. Values of the pharmacokinetic parameters suggest that glomerular filtration rate is lower in camels than in other ruminant species, horses, dogs and cats. Following i.m. administration of the dose (1.0 mg/kg), the drug was rapidly absorbed with peak serum concentration of 3.32 ± o.59 m̈g/ml at 20–30 min; the absorption half‐life was 3.9 ± 0.9 min. The systemic availability of tobramycin was 90.7 ± 14.4%. The apparent half‐life was 201 ±40 min, which was not significantly longer than the half‐life following i.v. administration of the drug. Based on the pharmacokinetic values obtained in this study, a dosing rate of 2.5 mg/kg administered by i.m. injection at 12‐h intervals can be recommended. This dosage regimen should achieve an average steady state serum concentration of 4 m̈g/ml with peak serum concentration approaching, but not exceeding, 10 m̈g/ml. Copyright © 1994, Wiley Blackwell. All rights reserved
Authors & Co-Authors
A/HADI, A. A.
United Arab Emirates, Al Ain
Veterinary Laboratory
Wasfi, Ibrahim Abdel Rahman
United Arab Emirates, Al Ain
United Arab Emirates University
Gadir, F. A.
United Arab Emirates, Al Ain
Veterinary Laboratory
AMIRI, M. H.
United Arab Emirates, Al Ain
United Arab Emirates University
Bashir, Ahrned K.
United Arab Emirates, Al Ain
United Arab Emirates University
Baggot, J. Desmond
Ireland, Naas
Irish Equine Centre
Statistics
Citations: 12
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1111/j.1365-2885.1994.tb00521.x
ISSN:
01407783
e-ISSN:
13652885