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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Field evaluation of crystal VC
®
rapid dipstick test for cholera during a cholera outbreak in Guinea-Bissau
Tropical Medicine and International Health, Volume 14, No. 9, Year 2009
Notification
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Description
Objectives To evaluate performance characteristics and ease of use of the new commercially available Crystal VC® Rapid Dipstick (VC) test (Span Diagnostics, India) for Vibrio cholerae O1 and O139. Methods Whole stool was collected from patients presenting to a hospital cholera ward during a 2008 epidemic in Guinea-Bissau. The VC test on stool samples was conducted on-site; samples were subsequently stored in Cary-Blair transport media and sent to the Centers for Disease Control and Prevention for diagnostic testing by culture and polymerase chain reaction (PCR). In addition, four local laboratory technicians who were unfamiliar with the test were provided with stool samples, the VC test kit, and simple written instructions and asked to perform the test and interpret results. Results A total of 101 stool specimens were collected and tested. Compared with PCR, the test was 97% sensitive and 71-76% specific. Laboratory technicians in Bissau performed the test and interpreted results correctly using only simple written instructions. Conclusions The VC test may be useful for cholera diagnosis in outbreak situations where laboratory capacity is limited. © 2009 Blackwell Publishing Ltd.
Authors & Co-Authors
Harris, Julie Rebecca
United States, Atlanta
Centers for Disease Control and Prevention
Cavallaro, Elizabeth C.
United States, Atlanta
Centers for Disease Control and Prevention
De Nóbrega, Aglaêr A.
Unknown Affiliation
Jean, Jean C.B.
Brazil, Brasilia
Field Epidemiology Training Program
Bopp, Cheryl A.
United States, Atlanta
Centers for Disease Control and Prevention
Parsons, Michele B.
United States, Atlanta
Centers for Disease Control and Prevention
Djalo, Djulde
Guinea-bissau
Hospital National Simao Mendes
Fonseca, Fatima G.Da S.
Guinea-bissau
Hospital National Simao Mendes
Ba, Umaro
Guinea-bissau
Hospital National Simao Mendes
Semedo, Agostinho
Guinea-bissau
Hospital National Simao Mendes
Sobel, Jeremy
United States, Atlanta
Centers for Disease Control and Prevention
Mintz, Eric Daniel
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 64
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1111/j.1365-3156.2009.02335.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Guinea
Guinea-Bissau