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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Detection and characterization of human caliciviruses in hospitalized children with acute gastroenteritis in Blantyre, Malawi
Journal of Medical Virology, Volume 77, No. 4, Year 2005
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Description
The human caliciviruses (HuCVs), including Norovirus and Sapovirus, are recognized causes of acute gastroenteritis in children and adults. A 1-year study was undertaken in Blantyre, Malawi, to examine the prevalence, and genetic diversity, of human caliciviruses (HuCVs) amongst children under 5 years of age hospitalized with acute gastroenteritis. Using the reverse transcription- polymerase chain reaction (RT-PCR), combined with nucleotide sequencing of the RT-PCR products, HuCVs were detected in 34/398 (8.5%) of children. Twelve (35.3%) of the children were co-infected with additional enteric viruses (predominantly rotavirus). The HuCVs comprised 26 Noroviruses (6.5%) and 8 Sapoviruses (2.0%). Each of the Noroviruses belonged to genogroup II, and could be further classified into six genotypes, including GII/3 (18 strains), GII/4 (2 strains), GII/11 (1 strain), GII/13 (1 strain), GII/16 (2 strains), and a putative new genotype GII/20 (2 strains). Each of the Sapoviruses belonged to genogroup GUI. HuCVs are the second most commonly identified viral enteropathogens (after rotavirus) among hospitalized children with gastroenteritis in Malawi. © 2005 Wiley-Liss, Inc.
Authors & Co-Authors
Dove, Winifred
United Kingdom, Liverpool
University of Liverpool
Cunliffe, Nigel A.
United Kingdom, Liverpool
University of Liverpool
Malawi, Zomba
University of Malawi
Gondwe, Jailosi S.
Malawi, Zomba
University of Malawi
Broadhead, Robin L.
Malawi, Zomba
University of Malawi
Molyneux, Malcolm Edward
United Kingdom, Liverpool
University of Liverpool
Nakagomi, Osamu
United Kingdom, Liverpool
University of Liverpool
Japan, Nagasaki
Nagasaki University
Hart, Charles Anthony
United Kingdom, Liverpool
University of Liverpool
Statistics
Citations: 78
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1002/jmv.20488
ISSN:
01466615
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Malawi