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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Radiometric evaluation of diglycolamide resins for the chromatographic separation of actinium from fission product lanthanides
Talanta, Volume 175, Year 2017
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Description
Actinium-225 is a potential Targeted Alpha Therapy (TAT) isotope. It can be generated with high energy (≥ 100 MeV) proton irradiation of thorium targets. The main challenge in the chemical recovery of 225Ac lies in the separation from thorium and many fission by-products most importantly radiolanthanides. We recently developed a separation strategy based on a combination of cation exchange and extraction chromatography to isolate and purify 225Ac. In this study, actinium and lanthanide equilibrium distribution coefficients and column elution behavior for both TODGA (N,N,N′,N′-tetra-n-octyldiglycolamide) and TEHDGA (N,N,N′,N′-tetrakis-2-ethylhexyldiglycolamide) were determined. Density functional theory (DFT) calculations were performed and were in agreement with experimental observations providing the foundation for understanding of the selectivity for Ac and lanthanides on different DGA (diglycolamide) based resins. The results of Gibbs energy (ΔGaq) calculations confirm significantly higher selectivity of DGA based resins for LnIII over AcIII in the presence of nitrate. DFT calculations and experimental results reveal that Ac chemistry cannot be predicted from lanthanide behavior under comparable circumstances. © 2017 Elsevier B.V.
Authors & Co-Authors
Radchenko, Valery I.
United States, Los Alamos
Los Alamos National Laboratory
Canada, Vancouver
Triumf
Engle, Jonathan W.
United States, Los Alamos
Los Alamos National Laboratory
United States, Madison
University of Wisconsin-madison
Wilson, Justin J.
United States, Los Alamos
Los Alamos National Laboratory
United States, Ithaca
Cornell University
Cutler, Cathy Sue
United States, Upton
Brookhaven National Laboratory
Mausner, Leonard F.
United States, Upton
Brookhaven National Laboratory
Nortier, Francois Meiring
United States, Los Alamos
Los Alamos National Laboratory
Fassbender, Michael E.
United States, Los Alamos
Los Alamos National Laboratory
Statistics
Citations: 23
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1016/j.talanta.2017.07.057
ISSN:
00399140