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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Prognostic value of proliferation assay in the luminal, HER2-positive, and triple-negative biologic classes of breast cancer
Breast Cancer Research, Volume 14, No. 1, Article R3, Year 2012
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Description
Introduction: Although the prognostic significance of proliferation in early invasive breast cancer has been recognized for a long time, recent gene-expression profiling studies have reemphasized its biologic and prognostic value and the potential application of its assessment in routine practice, particularly to define prognostic subgroups of luminal/hormone receptor-positive (HR +) tumors. This study aimed to assess the prognostic value of a proliferation assay by using Ki-67 immunohistochemistry as compared with mitotic count scores.Method: Proliferation was assessed by using Ki-67 labeling index (Ki-67LI) and mitotic scores in a large (n = 1,550) and well-characterized series of clinically annotated primary operable invasive breast cancer with long-term follow-up. Tumors were phenotyped based on their IHC profiles into luminal/HR +, HER2 +, and triple-negative (TN) classes. We used a split-sample development and validation approach to determine the optimal Ki-67LI cut-offs.Results: The optimal cut-points of Ki-67LI were 10% and 50% for the luminal class. Both Ki7LI and MS were able to split luminal tumors into subgroups with significantly variable outcomes, independent of other variables. Neither mitotic count scores nor Ki-67LI was associated with outcome in the HER2 + or the TN classes.Conclusions: Assessment of proliferation by using Ki-67LI and MS can distinguish subgroups of patients within luminal/hormone receptor-positive breast cancer significantly different in clinical outcomes. Overall, both Ki-67 LI and mitotic-count scores showed comparable results. The method described could provide a cost-effective method for prognostic subclassification of luminal/hormone receptor-positive breast cancer in routine clinical practice. © 2011 Alekandarany et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Aleskandarany, Mohammed A.
United Kingdom, Nottingham
Queen's Medical Centre
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Green, Andew R.
United Kingdom, Nottingham
Queen's Medical Centre
Benhasouna, Ahmed A.
United Kingdom, Nottingham
Queen's Medical Centre
Barros, Fabricio F.
United Kingdom, Nottingham
Queen's Medical Centre
Neal, Keith R.
United Kingdom, Nottingham
Queen's Medical Centre
Reis-Filho, Jorge Sérgio
United Kingdom, London
The Institute of Cancer Research
Ellis, Ian O.
United Kingdom, Nottingham
Queen's Medical Centre
Rakha, Emad A.
United Kingdom, Nottingham
Queen's Medical Centre
Statistics
Citations: 12
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1186/bcr3084
ISSN:
14655411
e-ISSN:
1465542X
Research Areas
Cancer
Genetics And Genomics
Study Design
Cohort Study