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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium
European Journal of Preventive Cardiology, Volume 27, No. 3, Year 2020
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Description
Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results: An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion: Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in individuals with the risk of future clinical endpoints. © The European Society of Cardiology 2019.
Authors & Co-Authors
Dörr, Marcus
Germany, Greifswald
Universitätsmedizin Greifswald
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Tuomainen, Tomi Pekka
Finland, Kuopio
Itä-suomen Yliopisto
Agewall, Stefan
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Ulleval University Hospital
Catapano, Alberico L.
Italy, Milan
Irccs Multimedica
Italy, Milan
Università Degli Studi Di Milano
Bots, Michiel L.
Netherlands, Utrecht
Universiteit Utrecht
Van Gilst, Wiek H.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Olsen, Michael Hecht
Denmark, Holbak
Holbæk Sygehus
Empana, Jean Philippe
France, Paris
Parcc - Paris-centre de Recherche Cardiovasculaire
Schminke, Ulf
Germany, Greifswald
Universitätsmedizin Greifswald
Baldassarre, D.
Italy, Milan
Irccs Centro Cardiologico Monzino
Italy, Milan
Università Degli Studi Di Milano
Veglia, Fabrizio
Italy, Milan
Irccs Centro Cardiologico Monzino
Franco, Oscar H.
Netherlands, Rotterdam
Erasmus Mc
Switzerland, Bern
University of Bern
Kavousi, Maryam
Netherlands, Rotterdam
Erasmus Mc
de Groot, Eric E.
Unknown Affiliation
Mathiesen, Ellisiv Bøgeberg
Norway, Tromso
Uit Norges Arktiske Universitet
Norway, Tromso
Universitetssykehuset Nord-norge
Polak, Joseph F.
United States, Boston
Tufts Medical Center
Rundek, Tatjana R.
United States, Coral Gables
University of Miami
Stehouwer, Coen D.A.
Netherlands, Maastricht
Universiteit Maastricht
Ntaios, George C.
Greece, Larissa
School of Health Sciences
Lind, Lars L.
Sweden, Uppsala
Uppsala Universitet
Willeit, Peter
Austria, Innsbruck
Medizinische Universitat Innsbruck
United Kingdom, Cambridge
University of Cambridge
Steinmetz, Helmuth
Germany, Frankfurt am Main
Goethe-universität Frankfurt am Main
Ikram, Mohammad Arfan
Netherlands, Rotterdam
Erasmus Mc
Johnsen, Stein Harald
Norway, Tromso
Uit Norges Arktiske Universitet
Norway, Tromso
Universitetssykehuset Nord-norge
Schmidt, Caroline
Sweden, Gothenburg
Sahlgrenska Akademin
Willeit, Johann
Austria, Innsbruck
Medizinische Universitat Innsbruck
Ducimetiére, Pierre P.
France, Gif-sur-yvette
Université Paris-saclay
Bergström, Göran M.L.
Sweden, Gothenburg
Sahlgrenska Akademin
Sweden, Gothenburg
Sahlgrenska Universitetssjukhuset
Kauhanen, Jussi
Finland, Kuopio
Itä-suomen Yliopisto
Kiechl, Stefan G.
Austria, Innsbruck
Medizinische Universitat Innsbruck
Sacco, Ralph L.
United States, Coral Gables
University of Miami
Hofman, Albert
Netherlands, Rotterdam
Erasmus Mc
United States, Boston
Harvard T.h. Chan School of Public Health
Völzke, Henry
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Germany, Greifswald
Universitätsmedizin Greifswald
Thompson, Simon G.
United Kingdom, Cambridge
University of Cambridge
Statistics
Citations: 11
Authors: 34
Affiliations: 42
Identifiers
Doi:
10.1177/2047487319877078
ISSN:
20474873
Research Areas
Environmental
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Systematic review