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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Analysis of dystrophin gene deletions by multiplex PCR in Moroccan patients
Journal of Biomedicine and Biotechnology, Volume 2002, No. 3, Year 2002
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Description
Duchenne and Becker muscular dystrophy (DMD and BMD) are X-linked diseases resulting from a defect in the dystrophin gene located on Xp21. DMD is the most frequent neuromuscular disease in humans (1/3500 male newborn). Deletions in the dystrophin gene represent 65% of mutations in DMD/BMD patients. We have analyzed DNA from 72 Moroccan patients with DMD/BMD using the multiplex polymerase chain reaction (PCR) to screen for exon deletions within the dystrophin gene, and to estimate the frequency of these abnormalities. We found dystrophin gene deletions in 37 cases. Therefore the frequency in Moroccan DMD/BMD patients is about 51.3%. All deletions were clustered in the two known hot-spots regions, and in 81% of cases deletions were detected in the region from exon 43 to exon 52. These findings are comparable to those reported in other studies. It is important to note that in our population, we can first search for deletions of DMD gene in the most frequently deleted exons determined by this study. This may facilitate the molecular diagnosis of DMD and BMD in our country. © 2002 Hindawi Publishing Corporation.
Authors & Co-Authors
Sbiti, Aziza
Morocco, Agdal Rabat
Institut National D'hygiène
El-Kerch, Fatiha
Morocco, Agdal Rabat
Institut National D'hygiène
Sefiani, Abdelaziz
Morocco, Agdal Rabat
Institut National D'hygiène
Statistics
Citations: 30
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1155/S1110724302205069
ISSN:
11107243
e-ISSN:
11107251
Research Areas
Disability
Genetics And Genomics
Study Design
Cross Sectional Study
Participants Gender
Male