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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Epithelioid sarcoma a clinicopathologic and immunohistochemical analysis of 106 cases from the french sarcoma group
American Journal of Clinical Pathology, Volume 131, No. 2, Year 2009
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Description
Epithelioid sarcoma (ES) is rare with a poor prognosis and for which a loss of INI1 expression has been recently reported. We report a study of 106 cases with clinical, histologic, and immunohistochemical data, including INI1 expression, and follow-up data. Of the 106 cases, 70 were the conventional subtype and 36 the large cell subtype. INI1 was negative in 86 cases (81.1%): 57 (81%) of 70 conventional and 29 (81%) of 36 large cell subtypes. Treatment modalities were available for 76 and follow-up for 80 patients. Of the 80 patients, 43 (54%) experienced metastasis and 25 (31%) died of the disease. Univariate analysis indicated that tumor size and mitotic index were significant for metastasis-free survival, whereas proximal location, tumor size, tumor multifocality, and mitotic index were significant for overall survival. Loss of expression of INI1 is frequent in the conventional and large cell subtypes of ES and can be used as a diagnostic marker, but it has no prognostic impact. © American Society for Clinical Pathology.
Authors & Co-Authors
Chbani, Laïla
France, Bordeaux
Institut Bergonie
Guillou, Louis
France, Villejuif
Institut de Cancerologie Gustave Roussy
Terrier-Lacombe, Marie José
France, Lyon
Le Centre Régional de Lutte Contre le Cancer Léon Bérard
Coindre, Jean Michél
France, Bordeaux
Institut Bergonie
France, Bordeaux
Université de Bordeaux
Statistics
Citations: 142
Authors: 4
Affiliations: 8
Identifiers
Doi:
10.1309/AJCPU98ABIPVJAIV
ISSN:
00029173
Research Areas
Cancer
Study Design
Cohort Study