Vitamin D Receptor in Breast Cancer Tissues and Its Relation to Estrogen Receptor Alpha (ER-α) Gene Expression and Serum 25-hydroxyvitamin D Levels in Egyptian Breast Cancer Patients: A Case-control Study

This case-control study was performed on 40 patients with breast cancer and 40 controls to investigate the role of vitamin D receptor in breast cancer tissues and its relation to estrogen receptor-α gene expression in the same tissues and serum 25-hydroxyvitamin D. Females with decreased levels of serum 25-hydroxyvitamin D, increased tissues levels of vitamin D receptor and increased tissue expression of estrogen receptor-α gene expression had significantly increased risk for breast cancer incidence.