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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Rivaroxaban with or without aspirin in stable cardiovascular disease
New England Journal of Medicine, Volume 377, No. 14, Year 2017
Notification
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Description
BACKGROUND: We evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention. METHODS: In this double-blind trial, we randomly assigned 27,395 participants with stable atherosclerotic vascular disease to receive rivaroxaban (2.5 mg twice daily) plus aspirin (100 mg once daily), rivaroxaban (5 mg twice daily), or aspirin (100 mg once daily). The primary outcome was a composite of cardiovascular death, stroke, or myocardial infarction. The study was stopped for superiority of the rivaroxaban-plus-aspirin group after a mean follow-up of 23 months. RESULTS: The primary outcome occurred in fewer patients in the rivaroxaban-plus-aspirin group than in the aspirin-alone group (379 patients [4.1%] vs. 496 patients [5.4%]; hazard ratio, 0.76; 95% confidence interval [CI], 0.66 to 0.86; P<0.001; z=−4.126), but major bleeding events occurred in more patients in the rivaroxaban-plus-aspirin group (288 patients [3.1%] vs. 170 patients [1.9%]; hazard ratio, 1.70; 95% CI, 1.40 to 2.05; P<0.001). There was no significant difference in intracranial or fatal bleeding between these two groups. There were 313 deaths (3.4%) in the rivaroxaban-plus-aspirin group as compared with 378 (4.1%) in the aspirin-alone group (hazard ratio, 0.82; 95% CI, 0.71 to 0.96; P=0.01; threshold P value for significance, 0.0025). The primary outcome did not occur in significantly fewer patients in the rivaroxaban-alone group than in the aspirin-alone group, but major bleeding events occurred in more patients in the rivaroxaban-alone group. CONCLUSIONS: Among patients with stable atherosclerotic vascular disease, those assigned to rivaroxaban (2.5 mg twice daily) plus aspirin had better cardiovascular outcomes and more major bleeding events than those assigned to aspirin alone. Rivaroxaban (5 mg twice daily) alone did not result in better cardiovascular outcomes than aspirin alone and resulted in more major bleeding events. Copyright © 2017 Massachusetts Medical Society.
Authors & Co-Authors
Eikelboom, John W.
Canada, Hamilton
Population Health Research Institute, Ontario
Connolly, Stuart J.
Canada, Hamilton
Population Health Research Institute, Ontario
Bosch, Jackie J.
Canada, Hamilton
Population Health Research Institute, Ontario
Dagenais, Gilles R.
Canada, Quebec
Institut Universitaire de Cardiologie et de Pneumologie de Québec - Université Laval
Hart, Robert G.
Canada, Hamilton
Population Health Research Institute, Ontario
Shestakovska, Olga
Canada, Hamilton
Population Health Research Institute, Ontario
Díaz, Rafaël J.
Argentina, Rosario
Instituto Cardiovascular de Rosario
Alings, Marco A.
Unknown Affiliation
Lönn, Eva Marie
Canada, Hamilton
Population Health Research Institute, Ontario
Anand, Sonia S.
Canada, Hamilton
Population Health Research Institute, Ontario
Widimsky, Petr
Czech Republic, Prague
Charles University
Hori, Masatusugu
Japan, Osaka
Osaka International Cancer Institute
Avezum, Álvaro Jr
Brazil, Sao Paulo
Instituto Dante Pazzanese de Cardiologia
Piegas, Leopoldo Soares
Brazil, Sao Paulo
Hospital do Coração
Branch, Kelley R.H.
United States, Seattle
Uw Medical Center – Montlake
Probstfield, Jeffrey L.
United States, Seattle
University of Washington
Bhatt, Deepak L.
United States, Boston
Harvard Medical School
Zhu, Jun
Unknown Affiliation
Liang, Yan
Unknown Affiliation
Maggioni, Aldo Pietro
Italy, Florence
Associazione Nazionale Medici Cardiologi Ospedalieri
López-Jaramillo, P.
Colombia, Bucaramanga
Fundación Oftalmológica de Santander
O'Donnell, Martin J.
Ireland, Galway
University of Galway
Kakkar, Ajay K.
United Kingdom, London
Thrombosis Research Institute
Fox, Keith A.A.
United Kingdom, Edinburgh
The University of Edinburgh
Ertl, Georg E.
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Störk, Stefan T.
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Keltai, Mátyás
Hungary, Budapest
Semmelweis Egyetem
Rydén, Lars
Sweden, Stockholm
Karolinska Institutet
Posogova, Nana
Russian Federation, Moscow
National Medical Research Center for Therapy and Preventive Medicine
Dans, Antonio L.L.
Philippines, Manila
University of the Philippines Manila
Lanas, Fernando T.
Chile, Temuco
Universidad de la Frontera
Commerford, Patrick Joseph
South Africa, Cape Town
University of Cape Town
Torp-Pedersen, Christian Tobias
Denmark, Aalborg
Aalborg University
Guzik, Tomasz Jan
United Kingdom, Glasgow
University of Glasgow
Poland, Krakow
Uniwersytet Jagielloński
Verhamme, Peter B.
Belgium, Leuven
Ku Leuven
Vinereanu, Dragoș
Romania, Bucharest
Universitatea de Medicina si Farmacie Carol Davila Din Bucuresti
Kim, Jae-hyung
South Korea, Bucheon-si
The Catholic University of Korea
Tonkin, Andrew Maxwell
Australia, Clayton
Monash University
Lewis, Basil S.
Israel, Haifa
Carmel Medical Center
Félix, Camilo
Ecuador, Quito
Universidad Ute
Yusoff, Khalid
Malaysia, Shah Alam
Universiti Teknologi Mara
Steg, Philippe Gabriel
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Metsärinne, Kaj P.
Finland, Turku
Turun Yliopistollinen Keskussairaala
Bruns, Nancy Cook
Germany, Leverkusen
Bayer ag
Misselwitz, Frank
Germany, Leverkusen
Bayer ag
Chen, Edmond
Germany, Leverkusen
Bayer ag
Leong, Darryl P.
Canada, Hamilton
Population Health Research Institute, Ontario
Yusuf, Salim N.
Canada, Hamilton
Population Health Research Institute, Ontario
Aboyans, Victor
Unknown Affiliation
Ha, Jong O.N.G.W.
Unknown Affiliation
Keltai, Katalin
Unknown Affiliation
Lamy, Andre L.
Unknown Affiliation
Liu, Lisheng
Unknown Affiliation
Moayyedi, Paul M.
Unknown Affiliation
Sharma, Mukul K.
Unknown Affiliation
Stöerk, Stefan
Unknown Affiliation
Varigos, John D.
Unknown Affiliation
Bhagirath, Vinai C.
Unknown Affiliation
Bogaty, Peter M.
Unknown Affiliation
Botto, Fernando
Unknown Affiliation
Catanese, Luciana
Unknown Affiliation
Donato Magno, J.
Unknown Affiliation
Fabbri, Gianna
Unknown Affiliation
Gabizon, Itzhak
Unknown Affiliation
Gosselin, Gilbert
Unknown Affiliation
Halon, D.
Unknown Affiliation
Heldmann, M.
Unknown Affiliation
Lamelas, Pablo Manuel
Unknown Affiliation
Lauw, Mandy N.
Unknown Affiliation
Leong, Yew Pung
Unknown Affiliation
Liang, Dongjie
Unknown Affiliation
Lutai, Ya M.
Unknown Affiliation
Maly, Martin
Unknown Affiliation
Mikulík, Robert
Unknown Affiliation
Nayar, Sumiti
Unknown Affiliation
Ng, Kelvin Kuan Huei
Unknown Affiliation
Perera, Kanjana Sashi
Unknown Affiliation
Pirvu, Octavian
Unknown Affiliation
Ronner, Eelko F.
Unknown Affiliation
Sato, S.
Unknown Affiliation
Smyth, Andrew
Unknown Affiliation
Sokolova, Elena V.
Unknown Affiliation
Wiendl, Martin
Unknown Affiliation
Winkelmann, Bernhard Rudolf
Unknown Affiliation
Yang, Xiaomeng
Unknown Affiliation
Yufereva, Y. M.
Unknown Affiliation
Cairns, J. A.
Unknown Affiliation
Sleight, Peter J.
Unknown Affiliation
DeMets, David L.
Unknown Affiliation
Momomura, Shin'ichi
Unknown Affiliation
Prins, Martin H.
Unknown Affiliation
Ramsay, Timothy O.
Unknown Affiliation
Goto, Shinya
Unknown Affiliation
Rouleau, Jean-Lucien Lucien
Unknown Affiliation
Schumi, Jennifer
Unknown Affiliation
Thabane, Lehana
Unknown Affiliation
Casanova, Amparo
Unknown Affiliation
Bangdiwala, Shrikant I.
Unknown Affiliation
Deng, E.
Unknown Affiliation
Dyal, Leanne
Unknown Affiliation
Khatun, Rutaba
Unknown Affiliation
Marsden, Tamara
Unknown Affiliation
Pogue, Janice M.
Unknown Affiliation
Yuan, Fei
Unknown Affiliation
Hamilton, Leah G.
Unknown Affiliation
Thomas, Sabu V.
Unknown Affiliation
Tyrwhitt, Jessica
Unknown Affiliation
Lanius, Vivian
Unknown Affiliation
Merten, Constanze
Unknown Affiliation
Muehlhofer, Eva
Unknown Affiliation
Tasto, Christoph
Unknown Affiliation
Orlandini, Andrés D.
Unknown Affiliation
Toscanelli, S.
Unknown Affiliation
Oliveira, Gustavo B.F.
Unknown Affiliation
Turbide, Ginette
Unknown Affiliation
Cayer, M.
Unknown Affiliation
Dušek, Radovan
Unknown Affiliation
Paucar, María José
Unknown Affiliation
Simon, Tabassome
Unknown Affiliation
Epstein, Laurence Mark
Unknown Affiliation
Schut, Astrid
Unknown Affiliation
Commerford, Anita
Unknown Affiliation
Lee, Shunfu
Unknown Affiliation
Anderson, Jeffrey L.
Unknown Affiliation
Sala, Jorgelina M.
Unknown Affiliation
Cartasegna, Luis Rodolfo
Unknown Affiliation
Beltrano, C.
Unknown Affiliation
Vico, Marisa Liliana
Unknown Affiliation
Lanchiotti, Paulina Virginia
Unknown Affiliation
Martella, Carolina
Unknown Affiliation
Hominal, Miguel Angel
Unknown Affiliation
Hasbani, Eduardo G.
Unknown Affiliation
Prado, Aldo
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Caccavo, Alberto
Unknown Affiliation
Zaidman, Cesar Javier
Unknown Affiliation
Guerlloy, Fernando P.
Unknown Affiliation
Vogel, Daniel R.
Unknown Affiliation
Domínguez, Antonio Reyes
Unknown Affiliation
Hrabar, Adrián D.
Unknown Affiliation
Fernández, Alberto Alfredo
Unknown Affiliation
Schygiel, Pablo Omar
Unknown Affiliation
Cuneo, Carlos Alberto
Unknown Affiliation
Lúquez, Hugo A.
Unknown Affiliation
MacKinnon, Ignacio J.
Unknown Affiliation
Ahuad-Guerrero, Rodolfo Andres
Unknown Affiliation
Costabel, Juan Pablo
Unknown Affiliation
Bartolacci, Ines Palmira
Unknown Affiliation
Montaña, Oscar R.
Unknown Affiliation
Camino, Alejandra Mabel
Unknown Affiliation
Crespo, Claudia J.
Unknown Affiliation
Barbieri, Maria
Unknown Affiliation
López Santi, Ricardo G.
Unknown Affiliation
Gomez Vilamajó, Oscar Alberto
Unknown Affiliation
Garcia-Duran, Ruben Omar
Unknown Affiliation
Schiavi, Lilia Beatriz
Unknown Affiliation
Bordonava, Anselmo Paulino
Unknown Affiliation
Rodríguez, Manuel A.
Unknown Affiliation
Garrido, Marcelo A.
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Ingaramo, Adrián C.
Unknown Affiliation
Costamagna, Osvaldo J.A.
Unknown Affiliation
Almagro, Sandra
Unknown Affiliation
Gerbaudo, Claudio
Unknown Affiliation
Pelagagge, María Jose
Unknown Affiliation
Bustamante-Labarta, Miguel H.
Unknown Affiliation
Novaretto, Leonardo P.
Unknown Affiliation
Albisu Di Gennero, Juan Pablo
Unknown Affiliation
Ibanez Saggia, Luz Maria
Unknown Affiliation
Vita, Néstor Alejandro
Unknown Affiliation
Macín, Stella Maris
Unknown Affiliation
Dran, Ricardo Dario
Unknown Affiliation
Cardona, Marcelo
Unknown Affiliation
Guzmán, Luis U.I.S.
Unknown Affiliation
Sarjanovich, Rodolfo Juan
Unknown Affiliation
Cuadrado, Jesus A.
Unknown Affiliation
Nani, Sebastián
Unknown Affiliation
Guardiani, Fernando Martin
Unknown Affiliation
Litvak-Bruno, Marcos Raul
Unknown Affiliation
Chacón, Carolina
Unknown Affiliation
Maffei, Laura Elena
Unknown Affiliation
Grinfeld, Diego D.
Unknown Affiliation
Vensentini, Natalia
Unknown Affiliation
Majul, Claudio Rodolfo
Unknown Affiliation
Luciardi, Héctor Lucas
Unknown Affiliation
Gonzalez Colaso, Patricia Del Carmen
Unknown Affiliation
Ferré Pácora, Fredy Antoni
Unknown Affiliation
Parody, Maria Leonor
Unknown Affiliation
Colquhoun, David M.
Unknown Affiliation
Williams, Lyn Keoki
Unknown Affiliation
Shaw, James A.M.
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Amerena, John V.
Unknown Affiliation
Royse, A. G.
Unknown Affiliation
Royse, Colin Forbes
Unknown Affiliation
Selvanayagam, JOSEPH B.
Unknown Affiliation
Thompson, Peter Lindsay
Unknown Affiliation
Hammett, Christopher J.K.
Unknown Affiliation
van den Heuvel, P. A.U.L.
Unknown Affiliation
Sinnaeve, Peter R.
Unknown Affiliation
Fourneau, Inge A.M.
Unknown Affiliation
Meuris, Bart
Unknown Affiliation
Vanassche, Thomas
Unknown Affiliation
Ector, Bavo
Unknown Affiliation
Janssens, Luc
Unknown Affiliation
Debonnaire, Philippe J.M.R.
Unknown Affiliation
Vandekerckhove, Yves R.
Unknown Affiliation
van de Borne, Philippe J.H.
Unknown Affiliation
Motte, Serge
Unknown Affiliation
Leroy, J. E.A.N.
Unknown Affiliation
Schroé, Herman H.
Unknown Affiliation
Vrolix, Mathias C.M.
Unknown Affiliation
Vranckx, Pascal
Unknown Affiliation
Elegeert, I. V.A.N.
Unknown Affiliation
Hoffer, Etienne P.
Unknown Affiliation
Dujardin, Karl
Unknown Affiliation
Précoma, Dalton Bertolim
Unknown Affiliation
Abrantes, José Antonio M.
Unknown Affiliation
Manenti, Euler Roberto Fernandes
Unknown Affiliation
Reis, Gilmar
Unknown Affiliation
Saraiva, José Francisco Kerr
Unknown Affiliation
Maia, Lília Nigro
Unknown Affiliation
Hernandes, Mauro Esteves
Unknown Affiliation
Zimmermann, Sergio Luiz
Unknown Affiliation
Botelho, Roberto Vieira
Unknown Affiliation
Dutra, Óscar Pereira
Unknown Affiliation
Nicolau, José Carlos
Unknown Affiliation
Minelli, César
Unknown Affiliation
Tytus, Richard H.
Unknown Affiliation
Nagpal, A. Dave
Unknown Affiliation
Anderson, Todd J.
Unknown Affiliation
Kieser, Teresa Mary
Unknown Affiliation
Fedak, Paul W.M.
Unknown Affiliation
Smith, Eric Edward
Unknown Affiliation
Hassan, Ahmed M.M.
Unknown Affiliation
Pelletier, Marc P.
Unknown Affiliation
Petrella, Robert John
Unknown Affiliation
Vijayaraghavan, Ram
Unknown Affiliation
Welsh, Robert C.
Unknown Affiliation
Della-Siega, Anthony J.
Unknown Affiliation
Dagenais, François
Unknown Affiliation
Nguyen, Michel
Unknown Affiliation
Hartleib, Michael C.
Unknown Affiliation
Guzman, Randolph P.
Unknown Affiliation
Khaykin, Yaariv
Unknown Affiliation
Bélisle, Patrick
Unknown Affiliation
Gagné, Claudé E.
Unknown Affiliation
Johnston, James Cameron
Unknown Affiliation
Montigny, Martine
Unknown Affiliation
Moussa, Fethia Ben
Unknown Affiliation
Corbalàn, Ramõn L.
Unknown Affiliation
Nahuelpan, Leonardo
Unknown Affiliation
Jiang, Lixin
Unknown Affiliation
Ge, Junbo
Unknown Affiliation
Hu, Taohong
Unknown Affiliation
Zhao, Yusheng
Unknown Affiliation
Wang, Rutao
Unknown Affiliation
Hu, Dayi
Unknown Affiliation
Wang, Michael K.
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Chen, Yingmin
Unknown Affiliation
Sun, Xiang
Unknown Affiliation
Zhang, Bingchang
Unknown Affiliation
Rocha, C.
Unknown Affiliation
Urina-Triana, Miguel
Unknown Affiliation
Aroca-Martínez, G.
Unknown Affiliation
Pérez-Mayorga, Maritza
Unknown Affiliation
Molina, Dora Ines
Unknown Affiliation
Sánchez-Vallejo, Gregorio
Unknown Affiliation
Gomez Mesa, Juan Esteban
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Bělohlávek, Jan
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Kovárník, Tomáš
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Kryza, Radim
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Špinar, Jindřich
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Pařenica, Jiří
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Poloczek, Martin
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Miklík, Roman
Unknown Affiliation
Kaňovský, Jan
Unknown Affiliation
Matuška, Jiří
Unknown Affiliation
Jankovic, Moncilo B.
Unknown Affiliation
Radvan, Martin
Unknown Affiliation
Mot'ovská, Zuzana
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Petr, Róbert
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Fischerová, Michaela
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Branný, Marián
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Adámková, Věra
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Sp̌inarová, Lenka
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Polášek, Rostislav
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Coufal, Zdeněk
Unknown Affiliation
Berger, Peter B.
Unknown Affiliation
Janský, Petr
Unknown Affiliation
Bruun, Niels Eske
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Bang, Lia Evi
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Olsen, Michael Hecht
Unknown Affiliation
Refsgaard, Jens
Unknown Affiliation
Duarte, Yan Carlos
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Perugachi, Carmita
Unknown Affiliation
Tuomilehto, Jaakko O.I.
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Kantola, Ilkka M.
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Feldman, Laurent J.
Unknown Affiliation
Ducrocq, Grégory
Unknown Affiliation
Leclercq, Florence L.
Unknown Affiliation
Roubille, Franc¸ois
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Agullo, Audrey
Unknown Affiliation
Ferrari, Émile
Unknown Affiliation
Moceri, Pamela
Unknown Affiliation
Boccara, Franck
Unknown Affiliation
Edérhy, Stéphane
Unknown Affiliation
Soulat-Dufour, Laurie
Unknown Affiliation
Cohen, Alexander Thomas
Unknown Affiliation
Mismetti, Patrick
Unknown Affiliation
Bertoletti, Laurent
Unknown Affiliation
Cayla, Guillaume
Unknown Affiliation
Souteyrand, Géraud
Unknown Affiliation
Krackhardt, Florian
Unknown Affiliation
Stellbrink, Christoph
Unknown Affiliation
Kadel, Christoph
Unknown Affiliation
Kimmel, Stephen E.
Unknown Affiliation
Opitz, Christian F.
Unknown Affiliation
Darius, Harald
Unknown Affiliation
Schellong, Sebastian M.
Unknown Affiliation
Müeller, Christian Eugen
Unknown Affiliation
Davierwala, Piroze Minoo
Unknown Affiliation
Misfeld, Martin
Unknown Affiliation
Haensig, Martin
Unknown Affiliation
Bajnok, László
Unknown Affiliation
Boda, Zoltán
Unknown Affiliation
McAdam, Brendan F.
Unknown Affiliation
Murphy, Andrew W.
Unknown Affiliation
Canavan, M. D.
Unknown Affiliation
Zimlíchman, Reuven R.
Unknown Affiliation
Zeltser, David W.
Unknown Affiliation
Halabi, Susan
Unknown Affiliation
Halon, David A.
Unknown Affiliation
Statistics
Citations: 1,658
Authors: 330
Affiliations: 35
Identifiers
Doi:
10.1056/NEJMoa1709118
ISSN:
00284793
Research Areas
Disability
Environmental
Noncommunicable Diseases
Study Design
Cohort Study