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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Search for a gene expression signature of breast cancer local recurrence in young women
Clinical Cancer Research, Volume 18, No. 6, Year 2012
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Description
Purpose: A gene expression signature, predictive for local recurrence after breast-conserving treatment, has previously been identified from a series of 165 young patients with breast cancer. We evaluated this signature on both another platform and an independent series, compared its performance with other published gene-sets, and investigated the gene expression profile of a larger data set. Experimental Design: Gene expression tumor profiles were obtained on 148 of the initial 165 Dutch patients and on an independent validation series of 195 French patients. Both unsupervised and supervised classifications were used to study the gene expression profile of the 343 breast cancers and to identify subgroups that differ for their risk of local recurrence. Results: The previous local recurrence signature was validated across platforms. However, when applied to the French patients, the signature did not reproduce its reported performance and did not better classify the patients than other published gene sets. Hierarchical clustering of all 343 breast cancers did not show any grouping reflecting local recurrence status. Genes related to proliferation were found differentially expressed between patients with or without local recurrence only in triple-negative tumors. Supervised classification revealed no significant gene set predictive for local recurrence or able to outperform classification based on clinical variables. Conclusions: Although the previously identified local recurrence signature was robust on another platform, we were neither able to validate it on an independent data set, nor able to define a strong gene expression classifier for local recurrence using a larger data set. We conclude that there are no significant differences in gene expression pattern in tumors from patients with and without local recurrence after breastconserving treatment. ©2012 AACR.
Authors & Co-Authors
Servant, Nicolas
France, Paris
Institut Curie
France, Paris
Cancer et Génome : Bioinformatique, Biostatistiques et Épidémiologie Des Systèmes Complexes
France, Paris
Mines Paris - Psl
Bollet, Marc Andrew
France, Paris
Institut Curie
Halfwerk, Hans
Netherlands, Amsterdam
The Netherlands Cancer Institute
Netherlands, Amsterdam
Neurochirurgisch Centrum Amsterdam
Bleakley, Kevin
France, Paris
Institut Curie
France, Paris
Cancer et Génome : Bioinformatique, Biostatistiques et Épidémiologie Des Systèmes Complexes
France, Paris
Mines Paris - Psl
France, Le Chesnay
Inria Institut National de Recherche en Informatique et en Automatique
Kreike, Bas
Netherlands, Amsterdam
Neurochirurgisch Centrum Amsterdam
Netherlands, Arnhem
Institute for Radiation Oncology Arnhem
Jacob, Laurent
France, Paris
Institut Curie
France, Paris
Cancer et Génome : Bioinformatique, Biostatistiques et Épidémiologie Des Systèmes Complexes
France, Paris
Mines Paris - Psl
United States, Berkeley
University of California, Berkeley
Sie, Daoud
Netherlands, Amsterdam
The Netherlands Cancer Institute
Kerkhoven, Ron M.
Netherlands, Amsterdam
The Netherlands Cancer Institute
Hupé, Philippe
France, Paris
Institut Curie
France, Paris
Cancer et Génome : Bioinformatique, Biostatistiques et Épidémiologie Des Systèmes Complexes
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Paris
Mines Paris - Psl
Hadhri, Rym
Tunisia, Monastir
Chu Fattouma-bourguiba
Fourquet, Alain
France, Paris
Institut Curie
Bartelink, Harry G.M.M.
Netherlands, Amsterdam
The Netherlands Cancer Institute
Barillot, Emmanuel
France, Paris
Institut Curie
France, Paris
Cancer et Génome : Bioinformatique, Biostatistiques et Épidémiologie Des Systèmes Complexes
France, Paris
Mines Paris - Psl
Sigal-Zafrani, Brigitte
France, Paris
Institut Curie
Van De Vijver, Marc J.
Netherlands, Amsterdam
The Netherlands Cancer Institute
Netherlands, Amsterdam
Neurochirurgisch Centrum Amsterdam
Statistics
Citations: 67
Authors: 15
Affiliations: 10
Identifiers
Doi:
10.1158/1078-0432.CCR-11-1954
ISSN:
10780432
e-ISSN:
15573265
Research Areas
Cancer
Genetics And Genomics
Participants Gender
Female